Gene: TP53 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.030 Biomarker disease BEFREE CA and Res also altered p53 and nuclear factor-κB (NF-κB) activation and expression in tBH-treated cell and fly models of SCA3, respectively. 28912527 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.030 Biomarker disease BEFREE We report that persistent accumulation of DNA damage/strand breaks and chronic activation of the serine/threonine kinase ATM and the downstream p53 and protein kinase C-δ pro-apoptotic pathways trigger neuronal dysfunction and eventually neuronal death in SCA3. 25590633 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.030 Biomarker disease BEFREE Intraperitoneal administration of p53 inhibitor pifithrin-α significantly ameliorated neuronal death in the pontine nuclei of SCA3 transgenic mice. 21092747 2011