| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | Biomarker | disease | BEFREE | The conjugation of antibodies against glycophorin A targeted the nanocarriers to <i>Plasmodium</i>-infected red blood cells and to gametocytes, the sole malaria parasite stage responsible for the transmission from the human to the mosquito vector. | 31315185 | 2019 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | DUP4 is a complex structural genomic variant that carries extra copies of a glycophorin A-glycophorin B fusion gene and has a dramatic effect on malaria risk by reducing the risk of severe malaria by up to 40%. | 30388403 | 2018 | ||||
|
0.370 | Biomarker | disease | BEFREE | Erythrocyte binding antigens 175 (EBA-175) and 140 (EBA-140) play key roles in erythrocyte invasion by binding to glycophorin A (GPA) and C (GPC) respectively in human malaria. | 29128519 | 2018 | ||||
|
0.370 | Biomarker | disease | BEFREE | These results are consistent with malaria acting as a selective pressure on GYPA, but also suggest that another selective force has resulted in a similar pattern of variation in Europeans. | 29362874 | 2018 | ||||
|
0.370 | Biomarker | disease | BEFREE | These findings suggest an essential role of the MSP1-GPA-band 3 complex during the initial adhesion phase of malaria parasite invasion of RBCs. | 25778531 | 2015 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | By contrast, we observed an allele frequency spectrum skewed toward a significant excess of intermediate-frequency alleles at GYPA exon 2 in many populations; the degree of spectrum distortion is correlated with malaria exposure, possibly because of the joint effects of gene conversion and balancing selection. | 21664997 | 2011 | ||||
|
0.370 | Biomarker | disease | BEFREE | GPA is the receptor for the binding ligand EBA-175 of the malaria parasite, Plasmodium falciparum. | 12949139 | 2003 | ||||
|
0.370 | Biomarker | disease | CTD_human |