Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Tumor necrosis factor-related apoptosis inducing ligand gene polymorphisms are correlated with gastric cancer in central China. 24277417 2015
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE TNF-α-G308A (rs1800629) polymorphisms are associated with gastric cancer in Chinese population. 27373488 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Only polymorphisms at HLA-DQ, TNF and CYP2E genes may confer some protective effect against gastric cancer. 12115538 2002
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Polymorphisms in TNF-alpha rather than IL-1beta are associated with increased risk for gastric ulcers and gastric cancer in Japan. 17201881 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Relationship Between Tumor Necrosis Factor-α rs361525 Polymorphism and Gastric Cancer Risk: A Meta-Analysis. 29867530 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE In conclusion, TNF-α 238 G/A polymorphism is significantly associated with increased risk of gastric cancer, especially in Asians. 23900678 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE The TNF-α(-238) (G/A) genotype was significantly associated with a high risk of gastritis and gastric cancer (GC) (P = 0.001 and P = 0.002, resp.). 26504356 2015
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE The combined effects between the TNF gene and smoking on gastric cancer risk were also evaluated. 19615068 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE IL-1β-31CC, IL-1β-511TT genotype, and TNF-α-857T carrier may have protective effect against GC progression. 21246243 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE However, the frequencies of individual haplotypes C and D, which had opposite alleles at -1031, -863, and -857, showed statistically significant differences between the gastric cancer and duodenal ulcer (P=0.005 and P=0.02, respectively), suggesting that the TNF/LTA genotypes might play an opposite role in the pathogenesis of gastric cancer and duodenal ulcer. 15381184 2004
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE The study results revealed that IL-1β rs1143627: T > C, rs16944: C > T (p = 0.001;OR = 1.85; 95% CI 1.30-2.63) and rs1143633: G > A (p < 0.0001; OR = 2.53; 95% CI 1.67-3.83) and TNF-α rs1800630: C > A, rs1799964: T > C (p < 0.0001; OR = 2.31; 95% CI 1.54-3.46) polymorphisms significantly contributed toward GC risk. 30094865 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Besides, TNFA-857 locus may be related to GC risk, which demonstrated changeability of results in different contrasts. 18350251 2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Functional promoter -308G>A variant in tumor necrosis factor α gene is associated with risk and progression of gastric cancer in a Chinese population. 23326309 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Polymorphisms within interleukin-1 (IL1) and tumor necrosis factor alpha (TNFA) gene clusters are associated with an increased risk of gastric cancer. 20200422 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Polymorphisms in TNF and HSP70 showed a significant severity-dose-response as risk markers from preneoplastic lesions to gastric cancer in Mexican population, probably because of their association with an intense and sustained inflammatory response. 19626584 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Our study investigates the role of the IL-1B-31, IL-1RN and TNF-A-308 gene polymorphisms as risk factors for the development of GC in a Mexican population. 15540224 2005
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE In conclusion, IL-10-1082/-592 and TNF-A-308 genetic polymorphisms may not be the important contributors to GC in Korea. 15978325 2005
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Our meta-analyses suggest that TNF-<i>α</i> T-857C polymorphism may be associated with increased risk of gastric cancer and hepatocellular cancer development. 28115787 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE To investigate this inconsistency, we performed a meta-analysis of 36 studies for TNFA -308G>A polymorphism to evaluate the effect of TNFA on genetic susceptibility for gastritis and GC. 24072494 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE In the subgroup analysis, we found that TNF-α-238G/A polymorphism was associated with the increased risk of GC amongst Asians, especially in Chinese, but not in Caucasians. 30413607 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE In conclusion, IL-1beta, IL1-RN, and TNF-alpha genotypes are not associated with gastric cancer in Italian patients. 15927855 2005
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Large meta-analyses confirmed the association between IL8, IL10, TNF-b, TP53 and PSCA, while genetic variation at different genes such as XPG, PLCE1, HFE, ERCC5, EZH2, DOC2, CYP19A1, ALDH2, and CDH1 have been reported to be associated with GC risk. 24011243 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE The meta-analysis suggests that TNF-α 857C/T polymorphism is significantly associated with increased risk of gastric cancer, especially in Asians. 23821300 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE The present study is aimed at evaluating the role of TNF-α-308 (G → A) gene polymorphism and susceptibility to GC. 23828749 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Association between TNF-α-308 G/A gene polymorphism and gastric cancer risk: a systematic review and meta-analysis. 25125137 2014