Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Various clinicopathological factors for gastric cancer were not related to the preoperative detection of TNF in the serum. 7961104 1994
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE These results strongly suggest that up-regulation of WNT10A induced by TNFalpha and H. pylori might play key roles in human gastric cancer through activation of WNT--beta-catenin--TCF signaling pathway. 11494032 2001
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Only polymorphisms at HLA-DQ, TNF and CYP2E genes may confer some protective effect against gastric cancer. 12115538 2002
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE However, the frequencies of individual haplotypes C and D, which had opposite alleles at -1031, -863, and -857, showed statistically significant differences between the gastric cancer and duodenal ulcer (P=0.005 and P=0.02, respectively), suggesting that the TNF/LTA genotypes might play an opposite role in the pathogenesis of gastric cancer and duodenal ulcer. 15381184 2004
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Our study investigates the role of the IL-1B-31, IL-1RN and TNF-A-308 gene polymorphisms as risk factors for the development of GC in a Mexican population. 15540224 2005
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE These findings suggest that genetic polymorphisms in IL-8, IL-10 and TNFalpha may play important roles in developing gastric cancer in the Chinese population. 15579481 2005
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE In conclusion, IL-1beta, IL1-RN, and TNF-alpha genotypes are not associated with gastric cancer in Italian patients. 15927855 2005
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE In conclusion, IL-10-1082/-592 and TNF-A-308 genetic polymorphisms may not be the important contributors to GC in Korea. 15978325 2005
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE There was no difference in the genetic polymorphism of IL-1Beta-511, IL-1RN and TNF-A in the patients with gastric cancer regardless of H. pylori positivity compared with control. 16579840 2006
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Our findings suggest that two Th1-related polymorphisms (TNFA -308 A>G and IFNGR2 Ex7-128 C>T) may increase the risk of gastric cancer. 16885196 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Polymorphisms in TNF-alpha rather than IL-1beta are associated with increased risk for gastric ulcers and gastric cancer in Japan. 17201881 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Besides, TNFA-857 locus may be related to GC risk, which demonstrated changeability of results in different contrasts. 18350251 2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE We analyzed genotypes for HLA class I and II, tumor necrosis factor alpha, interleukin (IL)-1beta, IL-1 receptor, IL-4, IL-4Ralpha and IL-10 in 330 H. pylori-infected noncardia patients with GC and 190 H. pylori-infected nonulcer dyspeptic controls. 19544559 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE A gastric cancer (GC) cell line, AGS, has high-level expression of CD40, a tumor necrosis factor receptor (TNFR) family member. 19604505 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE The combined effects between the TNF gene and smoking on gastric cancer risk were also evaluated. 19615068 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Polymorphisms in TNF and HSP70 showed a significant severity-dose-response as risk markers from preneoplastic lesions to gastric cancer in Mexican population, probably because of their association with an intense and sustained inflammatory response. 19626584 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Tip alpha has the unique function of inducing TNF-alpha production by gastric cells in vitro and is assumed to be related with the development of gastritis and gastric cancer. 19751439 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Polymorphisms within interleukin-1 (IL1) and tumor necrosis factor alpha (TNFA) gene clusters are associated with an increased risk of gastric cancer. 20200422 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE These cytokine gene polymorphisms, as well as those of IL-1B, IL-1RN and TNF-A, may be used to identify groups at higher risk of gastric cancer and peptic ulcer, and those suitable for their prevention by H. pylori eradication therapy in Western populations. 20222161 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE Over expression of TNF-α showed a significant severity-dose-response as risk markers from preneoplastic lesions to gastric cancer. 20512382 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE Involvement of tumor necrosis factor-alpha in the upregulation of CXCR4 expression in gastric cancer induced by Helicobacter pylori. 20699000 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE IL-1β-31CC, IL-1β-511TT genotype, and TNF-α-857T carrier may have protective effect against GC progression. 21246243 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Human gastric cancer development with TNF-α-inducing protein secreted from Helicobacter pylori. 22459353 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Thus, the aim of this study was to investigate the effect of proinflammatory cytokine gene polymorphisms for IL-1β, IL-1RN and TNF-α on the development of GC in a Brazilian population. 22714811 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE To investigate the prognostic significance of tumor necrosis factor receptor (TNFR),-associated factor 6 (TRAF6),-and ubiquitin in gastric cancer patients. 23013936 2012