Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Overall, 78% of GC cases harbored one clinically relevant GA or more, with the most frequent alterations being found in TP53 (50%), ARID1A (24%), KRAS (16%), CDH1 (15%), CDKN2A (14%), CCND1 (9.5%), ERBB2 (8.5%), PIK3CA (8.6%), MLL2 (6.9%), FGFR2 (6.0%), and MET (6.0%). 25882375 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE CDH1 germ-line missense mutation identified by multigene sequencing in a family with no history of diffuse gastric cancer. 25981591 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 PosttranslationalModification disease BEFREE In this study, we systematically reviewed the studies of CDH1 hypermethylation and GC, and evaluated the association between CDH1 hypermethylation and GC using meta-analysis methods. 25926721 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 AlteredExpression disease BEFREE CDH1 was downregulated in diffuse-type GC tissues (P=0.0007) and showed a negative relationship with HOTAIR (r(2)=0.154, P=0.0354). 26136075 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 PosttranslationalModification disease BEFREE Furthermore, the involvement of DNMT3A in promoting GC cell migration was associated with the promoter methylation-mediated repression of CDH1. 25874772 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Carriers of CDH1 mutations are at risk for a highly penetrant, aggressive and early-onset diffuse-type gastric cancer, and these individuals are usually offered prophylactic total gastrectomy. 26363540 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Greater CDH1 1054del83 transcripts were observed in gastric cancer (GC) cell lines than human gastric mucosal epithelial cell line GES-1. 26674321 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE The aim of this study was to find the putative gastric cancer predisposing gene defect in a family with HDGC that had previously been tested negative for mutations in CDH1. 25576241 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 AlteredExpression disease BEFREE Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer. 26334097 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE The risk of development of gastric cancer is high in families affected b-y these syndromes, but only hereditary diffuse gastric cancer is genetically explained (caused by germline alterations of CDH1, which encodes E-cadherin). 25638682 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Cell adhesion was affected by mutations of CDH1 in 2 GCs. 24510342 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE In conclusion, this meta-analysis failed to confirm the association between the CDH1 C-160A polymorphism and risk of gastric cancer. 25599647 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 PosttranslationalModification disease BEFREE TP53 mutation, allelic deletion of the APC gene and nuclear staining of β-catenin are frequently detected in the intestinal phenotype of GC, whereas CDH1 gene mutation, microsatellite instability and DNA hypermethylation of MLH1 are common events in the gastric phenotype of GC. 26033320 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE We have shown that germline CDH1 mutations are associated with early onset of bilateral LCIS with or without ILC in women without a family history of gastric cancer. 24366306 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Gene-based analysis indicated a significant cumulative association of genetic variants in CDH1 with GC (all Ps <10). 25340495 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE We find associated candidate driver genes, and identify seven novel somatic mutations in CDH1, which is a well-known gastric cancer-associated gene. 24690483 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE This study evaluated the effect of PTG on health-related quality of life (HRQL) in asymptomatic individuals with identified CDH1 mutations at high risk for gastric cancer. 24424140 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE To our knowledge, this is the first Korean case of presymptomatic detection of CDH1 mutation, and it highlights the importance of genetic screening for individuals with a family history of GC, especially in high-risk geographical areas. 25187893 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease CTD_human Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. 24816253 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Germline inactivation of the E-cadherin gene (CDH1) is associated with hereditary diffuse gastric cancer (HDGC), a rare autosomal dominant syndrome predisposing to both diffuse gastric cancer (DGC) and lobular breast cancer (LBC). 24493355 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Early-onset diffuse gastric cancer associated with a de novo large genomic deletion of CDH1 gene. 23812922 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease BEFREE Among these genes, the mRNA ratio of CDH2 to CDH1 could distinguish the 15 diffuse-type GC samples from the 17 intestinal-type GC samples. 24728500 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE In this report, we describe a germline CDH1 c.48 G>C variant found in a 21 year old woman and her living great uncle, who were both diagnosed with gastric cancer and belong to a family with high incidence of this type of cancer. 25771876 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease BEFREE Laser capture microdissection combined with real-time polymerase chain reaction and Western blot were used to determine the expressions of Bmi-1, the cellular homologue of avian myelocytomatosis virus (c-Myc), enhancer of Zeste homolog 2 (EZH2), phosphatase and tensin homologue (PTEN) and epithelial cadherin (E-cadherin) in 20 GC specimens and the adjacent non-cancerous gastric tissues. 24393364 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Probands from two Danish families with gastric cancer and a history suggesting HDGC were screened for CDH1 gene mutations. 24389957 2014