Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 AlteredExpression disease BEFREE Relative expression of SNHG7 is upregulated in gastric cancer tissues and cells, and partially contributes to the development and progression of gastric cancer through regulation of p15 and p16 expressions. 29131253 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker disease BEFREE Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16. 25890171 2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 GeneticVariation disease BEFREE Overall, 78% of GC cases harbored one clinically relevant GA or more, with the most frequent alterations being found in TP53 (50%), ARID1A (24%), KRAS (16%), CDH1 (15%), CDKN2A (14%), CCND1 (9.5%), ERBB2 (8.5%), PIK3CA (8.6%), MLL2 (6.9%), FGFR2 (6.0%), and MET (6.0%). 25882375 2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 AlteredExpression disease BEFREE The Aζ value of the receiver-operator characteristic curve for methylated p16 was 0.899 for serum and PPWs, compared to that in GC tissues. 24817951 2014
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 PosttranslationalModification disease BEFREE The relationship between P16 gene promoter methylation and gastric cancer: a meta-analysis based on Chinese patients. 25693938 2014
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 PosttranslationalModification disease BEFREE However, there were no correlations of p16 promoter methylation with the TNM stage and Helicobacter pylori (HP) infection of GC (Tumor size: OR = 0.76, 95% CI: 0.14-4.07, P = 0.746; HP infection: OR = 1.31, 95% CI: 0.75-2.27, P = 0.342; respectively). 24610350 2014
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker disease BEFREE Cytotoxicity of 5-Aza-2'-deoxycytidine against gastric cancer involves DNA damage in an ATM-P53 dependent signaling pathway and demethylation of P16(INK4A). 23201008 2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 AlteredExpression disease BEFREE Targeted inactivation of HDAC2 restores p16INK4a activity and exerts antitumor effects on human gastric cancer. 23175521 2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker disease BEFREE On the other hand, the observed pattern of p16 (INK4A) hypermethylation suggests that this event is a good marker for the gastric cancer pathway in the Pará state population. 23504555 2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 AlteredExpression disease BEFREE Our results demonstrate that STAT3, but not STAT5, is involved in GC cell growth and cell cycle progression through regulation of gene expression, such as Bcl-2, p16(ink4a) and p21(waf1/cip1). 22328012 2012
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 GeneticVariation disease BEFREE To explore germline hypermethylation of the tumor suppressor genes MLH1, CDH1 and P16(INK4a) in suspected cases of hereditary gastric cancer (GC). 22228973 2012
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker disease BEFREE A great number of genes with promoter methylation have been observed in gastric cancer (GC), among which p16INK4A (p16), Mut L homologue 1 (MLH1), Epithelial-cadherin (E-cadherin), Runt-related transcription factor 3 (RUNX3), adenomatous polyposis coli (APC), O(6)-methylguanine-DNA methyltransferase (MGMT), Ras association domain family 1A (RASSF1A) and Death-associated protein kinase (DAPK) have been extensively studied. 22936446 2012
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 PosttranslationalModification disease BEFREE We aimed to evaluate the inactivation of COX-2, HMLH1 and CDKN2A by promoter methylation and its relationship with the infection by different Helicobacter pylori strains in gastric cancer. 21849808 2011
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker disease BEFREE Evaluating LINE-1, TP53 and p16 jointly yielded a more pronounced negative association with gastric cancer (OR: 0.24; 95% CI: 0.09-0.66).Age was a significant effect modifier. 22126203 2011
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker disease BEFREE Up-regulation of activation-induced cytidine deaminase causes genetic aberrations at the CDKN2b-CDKN2a in gastric cancer. 20637757 2010
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 PosttranslationalModification disease BEFREE Methylation of the p16 gene is frequently detected in lymphatic-invasive gastric cancer. 20683001 2010
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker disease BEFREE E2F promoter-regulated oncolytic adenovirus with p16 gene induces cell apoptosis and exerts antitumor effect on gastric cancer. 19034663 2009
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 PosttranslationalModification disease BEFREE Methylation status of ANAPC1, CDKN2A and TP53 promoter genes in individuals with gastric cancer. 18622497 2008
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 GeneticVariation disease BEFREE The methylation level of the p16 gene was also associated with the presence of intestinal-type gastric cancer (p = 0.017). 17438355 2007
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker disease BEFREE The present study demonstrated for the first time that gastric cancer patients with p16INK4a methylation specifically benefit from 5-FU-based adjuvant chemotherapy. 18008030 2007
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker disease BEFREE We suggest that the carcinogenesis of EBV-associated gastric cancers may be closely associated with a p16 abnormality. 16619489 2006
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 PosttranslationalModification disease BEFREE Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer. 17139167 2006
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker disease CTD_human Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. 16367923 2006
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker disease BEFREE No precursor lesions were available from the gastric cancers that had loss of both MTAP and p16. 16224217 2005
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 AlteredExpression disease BEFREE 5-Aza-2'-deoxycitydine induces demethylation and up-regulates transcription of p16INK4A gene in human gastric cancer cell lines. 14733783 2004