| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.350 | GeneticVariation | disease | BEFREE | The aim of our study was to (a) test for an association between the BDNF Val66Met polymorphism and childhood-onset melancholic depression and (b) to examine the interactive effects of stressful life events (SLE) and the Val66Met polymorphism on the risk of childhood-onset melancholic depression. | 26462036 | 2015 | ||||
|
0.350 | GeneticVariation | disease | BEFREE | Val66Met BDNF genotypes in melancholic depression: effects on brain structure and treatment outcome. | 23165919 | 2013 | ||||
|
0.350 | GeneticVariation | disease | BEFREE | Recent post hoc analyses indicated a potential association of three polymorphisms in the BDNF gene with worse treatment outcome in patients with the subtype of melancholic depression. | 22965830 | 2013 | ||||
|
0.350 | GeneticVariation | disease | BEFREE | Key findings indicated that BDNF and 5-HTT polymorphisms in combination with ELS contributed to the development of non-melancholic depression. | 22247094 | 2012 | ||||
|
0.350 | Therapeutic | disease | CTD_human | Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: effects of fluoxetine and MK-801. | 21945287 | 2012 | ||||
|
0.350 | Biomarker | disease | CTD_human | Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: effects of fluoxetine and MK-801. | 21945287 | 2012 | ||||
|
0.350 | GeneticVariation | disease | BEFREE | However, BDNF rs7103411 and rs6265 similarly predicted worse treatment response over 6 wk in clinical subtypes of depression such as melancholic depression only (rs7103411: TT < CC, p = 0.003; rs6265: GG < AA, p = 0.001). | 19236730 | 2010 | ||||
|
0.350 | Biomarker | disease | CTD_human | Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats. | 16330021 | 2006 | ||||
|
0.350 | Therapeutic | disease | CTD_human | Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats. | 16330021 | 2006 |