|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The rarity of TERT promoter mutation in the acral lentiginous melanoma was consistent with the supposed role of UV light in the melanoma pathogenesis and also corroborated the view that acral lentiginous melanomas have a different pathogenesis with the melanomas from sun-exposed sites.
|
24588324 |
2014 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In melanoma a correlation has been suggested between the occurrence of TERT promoter mutations and v-RAF murine sarcoma viral oncogene homolog B1 (BRAF) mutations.
|
25035100 |
2014 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, frequent somatic mutations in the TERT promoter have been described in several tumor entities such as melanoma, glioblastoma, bladder cancer, and hepatocellular carcinoma.
|
25267585 |
2014 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Highly recurrent TERT promoter mutations in human melanoma.
|
23348506 |
2013 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 77% of areas of intermediate lesions and melanomas in situ harbored TERT promoter mutations, a finding that indicates that these mutations are selected at an unexpectedly early stage of the neoplastic progression.
|
26559571 |
2015 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TERT promoter mutations in sinonasal malignant melanoma: a study of 49 cases.
|
25746036 |
2015 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Herein, we describe the use of combined bisulfite restriction enzyme analysis (COBRA) as a diagnostic tool for detecting the hypermethylated TERT promoter using in vitro methylated and unmethylated genomic DNA as well as genomic DNA from four melanomas and two benign melanocytic lesions.
|
28284778 |
2017 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TERT promoter mutations are frequent in melanoma.
|
29123258 |
2018 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hence, combined targeting of RAS-ERK and TERT promoter remodeling is a promising avenue to limit long-term survival of a majority of melanomas that harbor these two mutations.
|
27911794 |
2016 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Coexistence of TERT promoter and BRAF mutations in cutaneous melanoma is associated with more clinicopathological features of aggressiveness.
|
26055532 |
2015 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The role of TERT promoter mutations in differentiating recurrent nevi from recurrent melanomas: A retrospective, case-control study.
|
30287318 |
2019 |
|
LOC110806263
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of TERT promoter germline mutations in families with melanoma in our population is extremely rare.
|
30451293 |
2019 |
|
LOC110806263
|
0.100 |
Biomarker
|
disease |
BEFREE |
Distribution of BRAF mutations did not differ across multiple melanomas (P = 0.85), whereas TERT promoter changes decreased from first to subsequent melanomas (P = 0.04).
|
29061376 |
2018 |
|
LOC110806263
|
0.100 |
Biomarker
|
disease |
BEFREE |
The etiology and pathogenesis of the pediatric melanoma is currently being investigated; studies have examined the genetic alterations that may be involved with the development of pediatric melanomas including TERT promoter, BRAF, and NRAS among others.
|
29485257 |
2018 |
|
LOC110806263
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although limited by sample size, our findings suggest that consideration be given to mutational analysis of metastatic tissue rather than the primary to guide BRAF-targeted therapy and question the roles of TERT promoter mutations and PD-L1 as predictive biomarkers in malignant melanoma.
|
30120967 |
2018 |
|
LOC110806263
|
0.100 |
Biomarker
|
disease |
BEFREE |
We then screened the TERT promoter in sporadic melanoma and observed recurrent ultraviolet signature somatic mutations in 125 of 168 (74%) of human cell lines derived from metastatic melanomas, 45 of 53 corresponding metastatic tumor tissues (85%), and 25 of 77 (33%) primary melanomas.
|
23348503 |
2013 |
|
LOC110806263
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we evaluated the detection of common mutations in BRAF, NRAS, and TERT promoter in 40 melanoma FFPE tissues using Droplet Digital (dd)PCR, and compared the results to the detection rates obtained by Sanger sequencing and pyrosequencing.
|
29305225 |
2018 |
|
LOC110806263
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that AdRGD combined with transcriptional regulation using Tyr or TERT promoter is a potentially useful and safe vector system for suicide gene therapy for melanoma.
|
15746944 |
2005 |