Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 Biomarker disease CTD_human Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression. 30619488 2018
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 GeneticVariation disease BEFREE The rarity of HRAS and KRAS Q61R mutants in malignant melanoma let previous investigations erroneously conclude that SP174 is specific for NRAS Q61R-mutant protein. 29206715 2018
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 Biomarker disease BEFREE Few studies have focused on the transcriptional level of RAS isoforms (KRAS, NRAS, and HRAS) in cutaneous melanoma. 29349077 2017
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 GeneticVariation disease CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 GeneticVariation disease BEFREE Integrative sequencing of cutaneous melanoma metastases using different sequencing platforms revealed a new somatic point mutation in HRAS and a structural rearrangement affecting CDKN2C (a CDK4 inhibitor). 23174022 2013
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 GeneticVariation disease BEFREE Association between HRAS rs12628 and rs112587690 polymorphisms with the risk of melanoma in the North American population. 22618666 2012
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 GeneticVariation disease BEFREE The second patient had malignant melanoma, in which we identified a somatic point mutation in HRAS and a structural rearrangement affecting CDKN2C. 22133722 2011
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 GeneticVariation disease BEFREE This was in accordance with the literature: review showed that no HRAS mutations had so far been reported in Spitzoid melanomas. 20871217 2010
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 Biomarker disease BEFREE We showed that HRAS activation cooperates with Pten+/- and Ink4a/Arf-/- to increase melanoma penetrance and promote metastasis. 20711233 2010
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 Biomarker disease BEFREE To look for evidence of progression from Spitz naevi to spitzoid melanoma, HRAS was analysed in 21 spitzoid melanomas, with no mutations identified. 19438459 2009
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 Biomarker disease BEFREE We have established a model of melanoma progression in zebrafish through the generation of transgenic lines specifically expressing oncogenic human HRAS in the melanocytic lineage. 20047469 2009
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 GeneticVariation disease BEFREE The impact of HRAS on the UPR was selective, as it was poorly induced by activated NRAS (more frequently mutated in melanoma than HRAS). 16964246 2006
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 GeneticVariation disease BEFREE We have investigated 37 sporadic malignant melanomas (15 primary cutaneous melanomas and 22 melanoma metastases) and 6 melanoma cell lines for mutations in the 3 Ras genes NRAS, KRAS and HRAS. 14961576 2004
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 Biomarker disease BEFREE HRAS activation by either mutation or copy number increase alone could explain several of the histological features that overlap with those of melanoma. 10980135 2000
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 Biomarker disease BEFREE Loci from these chromosome regions were chosen because of cytogenetic abnormalities reported in melanoma (1p, 6q, 9p), location of common oncogenes (11p-HRAS, 17p-TP53), or use in other MIN studies (5q, 18q). 9666803 1998
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 AlteredExpression disease BEFREE No significant differences were detected in the c-neu and Ha-ras mRNA levels in naevi and melanomas. 1686168 1991
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 Biomarker disease BEFREE Nodular melanoma, epithelioid cell type melanoma, and deeply invading melanoma revealed higher reactivity with anti-p21ras monoclonal antibody than the other types. 2664010 1989
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 AlteredExpression disease BEFREE The results of these studies are (1) 24% of cultured malignant melanomas have activated ras genes, with N-ras being activated ten times as frequently as Harvey (Ha)-ras. 2682463 1989
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 GeneticVariation disease BEFREE c-Ha-ras-1 alleles in bladder cancer, Wilms' tumour and malignant melanoma. 2892780 1988
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 GeneticVariation disease BEFREE These results imply that hereditary predisposition to melanoma is associated with genes other than the Ha-ras-1 locus, contradicting the original suggestion of Krontiris et al., made on the basis of either an inadequate sample size or other misleading experimental factors. 2879249 1987
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 GeneticVariation disease BEFREE However, the analysis of the same DNAs for a different polymorphism based on the presence of additional TaqI sites in the variable tandem repeat region of HRAS1 showed that the total frequency of a group of allelic variants, named Tp, was significantly higher in melanoma patients than in normal donors. 2894003 1987
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 AlteredExpression disease BEFREE Amplification of activated c-Ha-ras-1 in human melanoma. 3928549 1985
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 Biomarker disease BEFREE An SstI fragment of 2.9 kb carrying all four coding exons of the human melanoma c-Ha-ras-1 oncogene could not transform mouse NIH 3T3 cells. 3932274 1985
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 AlteredExpression disease BEFREE The activation of c-Ha-ras and N-ras has been described in some cell lines derived from cases of human malignant melanoma. 6090953 1984
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.800 GeneticVariation disease BEFREE Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient. 6087347 1984