Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 Biomarker disease BEFREE This novel mechanism for regulating NF1 in melanoma provides a molecular basis for targeting CAPN1 in order to stabilize NF1 levels and, in doing so, suppressing Ras activation; this mechanism can be exploited therapeutically in melanoma and other cancers. 30131853 2018
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 GeneticVariation disease BEFREE Our results warrant the clinical investigation of this combination therapy in patients with NF1 mutant melanoma. 28143781 2017
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 Biomarker disease BEFREE Melanogenesis in NF1 sets the stage for the discussion on the roles of NF1 and neurofibromin in neural crest-derived neoplasms including melanoma with particular emphasis on NF1 and neurofibromin as markers of melanocyte dedifferentiation in desmoplastic melanoma. 27941538 2017
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 AlteredExpression disease BEFREE As neurofibromin activity is a key to regulating the RAS/MAPK pathway, NF1 mutations are important in the acquisition of drug resistance, to BRAF, EGFR inhibitors, tamoxifen and retinoic acid in melanoma, lung and breast cancers and neuroblastoma. 28637487 2017
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 Biomarker disease BEFREE In this article, we review the literature on neurofibromin with special attention to keratinocytes, melanocytes, NF1-related tumors and melanoma. 27622733 2017
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 Biomarker disease BEFREE This review discusses the current knowledge of the NF1 gene and neurofibromin 1 in neurofibromatosis type I and in melanoma. 28067895 2017
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 Biomarker disease CTD_human Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas. 26214590 2015
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 Biomarker disease BEFREE The high frequency of NF1 mutations in DMs suggests an important role for NF1 in the biology of this type of melanoma. 26076063 2015
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 Biomarker disease CTD_human PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. 25119042 2014
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 Biomarker disease BEFREE Together these studies provide new insights into the signaling that underlies melanoma initiation and progression and suggests novel therapeutic strategies for patients whose melanomas are BRAF-mutant/NF1-deficient. 23475878 2013
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 GeneticVariation disease BEFREE Collectively, these studies provide mechanistic insight into how NF1 cooperates with BRAF mutations in melanoma and show that NF1/neurofibromin inactivation may have an impact on responses to targeted therapies. 23171796 2013
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 GeneticVariation disease BEFREE Somatic deletion of the NF1 gene in a neurofibromatosis type 1-associated malignant melanoma demonstrated by digital PCR. 16961930 2006
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 AlteredExpression disease BEFREE Eighteen (47%) of uveal melanomas demonstrated weak expression of neurofibromin. 12963615 2003
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 GeneticVariation disease LHGDN Eighteen (47%) of uveal melanomas demonstrated weak expression of neurofibromin. 12963615 2003
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 AlteredExpression disease BEFREE Loss of NF1 gene expression has been reported in Schwann cell tumors (neurofibrosarcomas) from patients with NF1 as well as in malignant melanomas and neuroblastomas from patients without NF1. 7542904 1995
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 Biomarker disease BEFREE By transiently coexpressing a neurofibromin cDNA in a melanoma cell line, we show that neurofibromin increases the expression of a reporter gene under the control of the tyrosinase gene promoter. 7811291 1994
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 Biomarker disease BEFREE Recent studies have demonstrated loss of neurofibromin in tumors from NF1 and non-NF1 patients, including neurofibrosarcomas, neuroblastomas and malignant melanomas. 7519874 1994
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 Biomarker disease BEFREE In contrast to the schwannoma cell lines, GTP-Ras was appropriately regulated in the melanoma and neuroblastoma lines that were deficient in neurofibromin, even when c-H-ras was overexpressed in the lines. 8516298 1993
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 CausalMutation disease CGI
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.600 GenomicAlterations disease CGI