Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5537
Gene Symbol: PPP6C
PPP6C
0.540 GeneticVariation disease BEFREE Additionally, we described a role for PP6C in this process and provided a mechanism for PP6C mutations associated with melanoma. 25759478 2015
Entrez Id: 5537
Gene Symbol: PPP6C
PPP6C
0.540 GeneticVariation disease BEFREE Among patients with primary melanoma with PP6C mutations, patients with stop mutations had significantly shorter recurrence-free survival compared with patients without stop mutations. 24336958 2014
Entrez Id: 5537
Gene Symbol: PPP6C
PPP6C
0.540 Biomarker disease BEFREE These findings support the view that formation of micronuclei rather than chromosome instability alone explains how loss of PPP6C, and more generally mitotic spindle and centrosome defects, can act as drivers for genome instability in melanoma and other cancers. 23729733 2013
Entrez Id: 5537
Gene Symbol: PPP6C
PPP6C
0.540 Biomarker disease CTD_human Among the newly identified cancer genes was PPP6C, encoding a serine/threonine phosphatase, which harbored mutations that clustered in the active site in 12% of sun-exposed melanomas, exclusively in tumors with mutations in BRAF or NRAS. 22842228 2012
Entrez Id: 5537
Gene Symbol: PPP6C
PPP6C
0.540 GeneticVariation disease BEFREE Among the newly identified cancer genes was PPP6C, encoding a serine/threonine phosphatase, which harbored mutations that clustered in the active site in 12% of sun-exposed melanomas, exclusively in tumors with mutations in BRAF or NRAS. 22842228 2012
Entrez Id: 5537
Gene Symbol: PPP6C
PPP6C
0.540 CausalMutation disease CGI