Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | Epidermal growth factor receptors EGFR and ErbB2 are overexpressed in schwannomas and meningiomas. | 29948766 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | This study was designed to investigate the expression of the intracellular and extracellular domains of EGFR and of the activated receptor as well as its ligands EGF and TGFα in a large series of meningiomas with long follow-up data, and investigate if there exists an association between antibody expression and clinical and histological data. | 28367377 | 2017 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Meningiomas express various hormonal and growth factor receptors, such as progesterone, estrogen, somatostatin, transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF) receptors, which may be related to their biological behavior and response to treatment. | 21227570 | 2011 | ||||
|
0.070 | Biomarker | disease | BEFREE | Our results indicate the inhibitory effect of IFN-alpha both on DNA synthesis promoted by PDGF and EGF, and on the meningioma cell proliferation. | 8687119 | 1996 | ||||
|
0.070 | Biomarker | disease | BEFREE | EGF-R was present in almost half and progesterone receptor in most of the meningiomas. | 7754837 | 1994 | ||||
|
0.070 | Biomarker | disease | BEFREE | Positive correlations between proliferation and proto-oncogene/growth factor expression were found for c-myc in atypical/malignant tumors and for epidermal growth factor in fibroblastic meningiomas. | 8133992 | 1993 | ||||
|
0.070 | Biomarker | disease | BEFREE | A consecutive series of six meningiomas and one meningioma/neurofibroma derived from a patient with neurofibromatosis type 2 was investigated and it was found that the growth of all seven tumours in response to mitotic stimuli (fetal bovine serum or epidermal growth factor) is strongly inhibited by IFN-alpha. | 1828169 | 1991 |