Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Notch and PI3K/AKT/mTOR) differences between convexity and skull base meningiomas. 31077268 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE The importance of NF2 (neurofibromin 2), TRAF7 (tumor necrosis factor [TNF] receptor-associated factor 7), KLF4 (Kruppel-like factor 4), AKT1, SMO (smoothened), PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), and POLR2 (RNA polymerase II subunit A) demonstrates that there are at least 6 distinct mutational classes of meningiomas. 29852774 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 GeneticVariation disease BEFREE Unilateral vestibular schwannoma and meningiomas in a patient with PIK3CA-related segmental overgrowth: Co-occurrence of mosaicism for 2 rare disorders. 28737257 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 GeneticVariation disease BEFREE We found a higher frequency of PIK3CA mutations [14/40 (35%) versus 18/530 (3%), P < 10-8] and TRAF7 mutations [16/40 (40%) versus 140/530 (26%), P < 0.001] and a lower frequency of NF2-related tumors compared with the control population of meningiomas [3/40 (7.5%) versus 169/530 (32%), P < 0.001]. 29206892 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 AlteredExpression disease BEFREE Meningiomas frequently display activation of the PI3K/AKT/mTOR pathway, leading to elevated levels of phospho-eukaryotic translation initiation factor 4E binding proteins, which enhances protein synthesis; however, it is not known whether inhibition of protein translation is an effective treatment option for meningiomas. 28610844 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 AlteredExpression disease BEFREE Importantly, the discovery of clinically actionable alterations in a number of genes, including SMO, AKT1 and PIK3CA, has opened up novel potential avenues for therapeutic management of meningiomas. 30379704 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE TAGLN2 can affect the proliferation, invasion and apoptosis of meningioma cells and may participate in the development of meningioma through regulating the PI3K/AKT signaling pathway. 29424888 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 AlteredExpression disease BEFREE We hypothesize that sporadic meningothelial and transitional subtype meningiomas are a forme fruste or microform of Proteus syndrome, and activation of the AKT/PI3K pathway drives hyperostosis in both non-syndromic, and Proteus-related meningiomas.© 2016 The Authors. 27550858 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 GeneticVariation disease BEFREE PIK3CA-mutant meningiomas showed limited chromosomal instability and were enriched in the skull base. 26826201 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Furthermore, PI3K/AKT may contribute to the carcinogenesis and development of human meningiomas in combination with HER-2. 25998419 2015
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 AlteredExpression disease BEFREE In conclusion, we proposed that activation of PI3K/Akt and integrin-mediated signaling pathways was involved in the pathogenesis of benign and anaplastic meningiomas, respectively. 23285163 2012
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease BEFREE Comparative protein profiling reveals minichromosome maintenance (MCM) proteins as novel potential tumor markers for meningiomas. 19877719 2010
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.200 Biomarker disease HPO