Gene: BMP15 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE Association of BMP15 and GDF9 variants to premature ovarian insufficiency. 31392662 2019
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 Biomarker disease BEFREE The role of BMP15 and GDF9 in the pathogenesis of primary ovarian insufficiency. 31607184 2019
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE The significant consequences of mutations in the GDF9 and BMP15 genes in women with dizygotic twins as well as the clinical relevance of these oocyte factors in the pathogenesis of primary ovarian insufficiency and polycystic ovary syndrome are also addressed. 29544636 2018
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE A novel homozygous mutation of bone morphogenetic protein 15 identified in a consanguineous marriage family with primary ovarian insufficiency. 29169851 2018
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9. 28359091 2017
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 Biomarker disease BEFREE BMP15 "knockout-like" effect in familial premature ovarian insufficiency with persistent ovarian reserve. 28094433 2017
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE A total of three SNPs were detected within the BMP15 gene, including rs3810682 (-9C>G), rs79377927 (788_789insTCT) and rs17003221 (852C>T), and no significant differences were observed in the frequencies of the -9C>G and 852C>T genotypes between the POF and control groups (7.94, vs. 6.90% and 4.76, vs. 3.45%, respectively). 25954833 2015
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE A novel FOXL2 gene mutation and BMP15 variants in a woman with primary ovarian insufficiency and blepharophimosis-ptosis-epicanthus inversus syndrome. 25988799 2015
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE A functional association between the BMP15 c.-9C>G promoter polymorphism and cause of POF have been reported. 25246117 2014
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE Positive selection in bone morphogenetic protein 15 targets a natural mutation associated with primary ovarian insufficiency in human. 24147118 2013
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE Previous studies have discovered several mutations in the screening of BMP15 in premature ovarian failure but none in PCOS. 22014425 2011
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE Similarly, large numbers of mutations in the GDF9 and BMP15 genes have been identified in women with premature ovarian failure and in mothers of dizygotic twins. 21226076 2011
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE Nine variants of the BMP15 gene including six missense substitutions and one insertion of three nucleotides were identified in the POF group. 20364024 2010
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE BMP15 mutations associated with primary ovarian insufficiency cause a defective production of bioactive protein. 19263482 2009
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE Caution is recommended in the interpretation of BMP15 mutations in the context of POF. 17826728 2008
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE Our findings indicate that mutations in BMP-15 exons, or changes in BMP-15 pro-peptide, are rare in Chinese women with POF. 17464588 2007
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE However, three single nucleotide polymorphisms in the BMP15 gene, two in the 5' untranslated region (31T>G and 71C>G) and another in exon 1 (387G>A), were found to be common in both POF and control groups. 17027369 2006
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE In the human, a heterozygous point mutation of BMP15 has been associated with premature ovarian failure (POF). 16645022 2006
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE Sequence analysis of the coding region of the BMP15 gene was carried out in a cohort of women with POF (n=133), primary amenorrhoea (n=60), and secondary amenorrhoea (n=9) compared with control females (n=197). 16508750 2006
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE The objective of the study was to verify the involvement of BMP15 variations in a large POF population. 16464940 2006
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 GeneticVariation disease BEFREE The missense mutation in the GDF-9 gene or the GDF-9B/BMP-15 gene is uncommon in anovulatory Japanese women with POF and PCOS. 11056243 2000
Entrez Id: 9210
Gene Symbol: BMP15
BMP15 		0.200 Biomarker disease HPO