Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE Several lines of evidence point out the relevance of nucleotide-binding oligomerization domain leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome as a pivotal player in the pathophysiology of several neurological and psychiatric diseases (i.e., Parkinson's disease (PD), Alzheimer's disease (AD), multiple sclerosis (MS), amyotrophic lateral sclerosis, and major depressive disorder), metabolic disorders (i.e., obesity and type 2 diabetes) and chronic inflammatory diseases (i.e., intestinal inflammation, arthritis, and gout). 31200447 2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE The NLRP3 inflammasome has emerged as an important regulator of metabolic disorders and age-associated diseases as reported in NLRP3 deficient mice. 31603987 2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE Endoplasmic reticulum stress and NLRP3 inflammasome: Crosstalk in cardiovascular and metabolic disorders. 30746697 2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE The NLRP3 inflammasome is associated with the onset and progression of autoinflammatory and autoimmune diseases, including metabolic disorders, multiple sclerosis, inflammatory bowel disease, and cryopyrin-associated periodic fever syndrome. 30666624 2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE In this review, we discuss the importance of the NLRP3 inflammasome in metabolic disorders and its close association with metabolic pathways. 29339210 2018
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE The NLRP3 inflammasome is implicated in many human pathologies including infections, autoinflammatory syndromes, chronic inflammation, and metabolic diseases; however, the molecular mechanisms of activation are not fully understood. 29358279 2018
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE Inappropriate NLRP3 inflammasome activation can induce autoinflammatory, autoimmune, or metabolic disorders. 29868015 2018
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 AlteredExpression group BEFREE The NLRP3 inflammasome must be well orchestrated to prevent the aberrant activations under physiological and pathological conditions, because uncontrolled activation of NLRP3 inflammasome is one of the major causes of a variety of autoimmune diseases and metabolic disorders. 30349539 2018
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE These findings demonstrate that excess SFAs cause intracellular crystallization and subsequent lysosomal dysfunction, leading to the activation of the NLRP3 inflammasome, and provide novel insights into the pathogenesis of metabolic diseases. 29437575 2018
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE Our results suggest that CO regulates glycolysis-dependent NLRP3 inflammasome activation and may provide a therapeutic approach for inflammation in metabolic diseases. 28942141 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE Importantly, BBR also prevented NLRP3 inflammasome-dependent inflammation and metabolic disorder in a high-fat-diet-induced insulin resistance model. 28282788 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE The molecular mechanisms underpinning these observations suggest that magnesium isoglycyrrhizinate may inhibit NF-κB/NLRP3 inflammasome activation to reduce immunological-inflammatory response, which in turn may prevent liver lipid metabolic disorder and accumulation under high fructose condition. 28526339 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE Studies suggest that disruption of NLRP1 and NLRP3 has a major role for these inflammasomes in internal immunity and inflammation as well as metabolic disorders. 29079203 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE The implication of the same complex, NLRP3 inflammasome, in different diseases such as cardiovascular, neurodegenerative, psychiatric, and metabolic diseases opens a door to develop new therapeutic perspectives. 28427559 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE IL-1β-secreting nucleotide-binding oligomerization domain protein 3 (NLRP3) inflammasomes play a pivotal role in triggering innate immune responses in metabolic disease. 25651569 2015
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE Moreover, the NLRP3 inflammasome has been implicated in chronic low-grade sterile inflammation characterizing metabolic disorders, though the mechanism(s) involved in inflammasome activation under these conditions are still unknown. 23843215 2013
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker group BEFREE The development of metabolic disorders is partly mediated by the NLR family pyrin domain containing-3 (NLRP3) inflammasome, which increases the secretion of inflammatory cytokines via activation of caspase-1. 24013717 2013