Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.100 Biomarker group BEFREE Alisol A attenuates high-fat-diet-induced obesity and metabolic disorders via the AMPK/ACC/SREBP-1c pathway. 31144451 2019
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.100 Biomarker group BEFREE The Potential Synergistic Modulation of AMPK by <i>Lippia citriodora</i> Compounds as a Target in Metabolic Disorders. 31817196 2019
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.100 Biomarker group BEFREE These findings suggested that AMPK activation is a potential therapy to prevent some of the metabolic disorders attributable to air pollution exposure. 31071567 2019
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.100 Biomarker group BEFREE Reduced spontaneous contractions, AMPK activation, cell apoptosis, and energy metabolism disorders were observed in gastric smooth muscle tissues of a diabetic rat, and AMPK activation was associated with an increased ratio of ADP/ATP, AMP/ATP, LKB1 activity, and CaMMKβ expression. 30968342 2019
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.100 Biomarker group BEFREE This regulatory connection between NRF2 and AMPK may have an important role in understanding how autophagy is regulated in chronic human morbidities characterized by oxidative stress, such as neurodegenerative diseases, certain cancer types, and in metabolic diseases.-Kosztelnik, M., Kurucz, A., Papp, D., Jones, E., Sigmond, T., Barna, J., Traka, M. H., Lorincz, T., Szarka, A., Banhegyi, G., Vellai, T., Korcsmaros, T., Kapuy, O. Suppression of AMPK/aak-2 by NRF2/SKN-1 down-regulates autophagy during prolonged oxidative stress. 30277819 2019
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.100 GeneticVariation group BEFREE The metabolic disorders in the liver and skeletal muscle were accompanied by the decrease in AMPK phosphorylation and activation of Akt. 29738801 2018
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.100 Biomarker group BEFREE AMPK is considered as a potential high value target for metabolic disorders. 29942003 2018
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.100 Biomarker group BEFREE Overall, our findings point to hypothalamic AMPK in specific neuronal populations as a potential druggable target for the treatment of obesity and associated metabolic disorders. 30104247 2018
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.100 Biomarker group BEFREE Gene silencing study revealed that Med promotes the development of brown- and beige-adipocyte characteristics in C3H10T1/2 mesenchymal stem cells through activation of the AMPK pathway, and our data allow us to propose Med as a candidate for therapeutics against obesity or related metabolic disorders.© 2017 BioFactors, 44(2):168-179, 2018. 29064586 2018
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.100 Biomarker group BEFREE Notably, the therapeutic potential of AMPK is widely recognized and heavily pursued for treatment of metabolic diseases such as diabetes, but also obesity, inflammation, and cancer. 28622524 2017
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.100 AlteredExpression group BEFREE Decreased expression of AMPKα1 as a result of increased levels of miR-130b and miR-148a may potentially explain the decrease in fat oxidation we reported in infants at 1 month of age and, if persistent, may predispose offspring to future metabolic disease. 27562513 2016
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.100 AlteredExpression group BEFREE Additionally, insulin-independent (heterologous) kinases can phosphorylate IRS1/2 under basal conditions (AMPK, GSK3) or in response to sympathetic activation and lipid/inflammatory mediators, which are present at elevated levels in metabolic disease (GRK2, novel and conventional PKCs, JNK, IKKβ, mPLK). 22869320 2012
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.100 Biomarker group BEFREE AMPK has emerged as a critical mechanism for salutary effects of polyphenols on lipid metabolic disorders in type 1 and type 2 diabetes. 21459323 2011
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.100 Biomarker group BEFREE We provide evidence that the adiponectin-AMPK pathway is the main mediator of the improvement of these metabolic disorders. 22016761 2011
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.100 Biomarker group BEFREE In humans, AMPK regulates lipid and glucose metabolism and has been implicated in such metabolic disorders as diabetes and obesity and in cardiac abnormalities. 12847291 2003