Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.550 Biomarker group CTD_human Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin. 24224046 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.550 Biomarker group CTD_mouse Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. 19435901 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.550 GeneticVariation group LHGDN Combined effects of the p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms on the risk of HPV16-associated oral cancer in never-smokers. 18701437 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.550 GeneticVariation group LHGDN Association between the TP53 codon72 polymorphism and oral cancer risk and prognosis. 17306604 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.550 Biomarker group RGD Diabetes alters expression of p53 and c-myc in different stages of oral oncogenesis. 17595763 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.550 GeneticVariation group LHGDN Association of p53 and p21(CDKN1A/WAF1/CIP1) polymorphisms with oral cancer in Taiwan patients. 17595776 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.550 Biomarker group LHGDN The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity. 15941720 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.550 GeneticVariation group BEFREE These data suggest that p53 mutation may be a very early event in oral cavity tumor progression and demonstrate that pre-malignant lesions obtained from non-tobacco users do not exhibit p53 mutations. 7829258 1995
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.520 Biomarker group RGD Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors. 20051374 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.520 AlteredExpression group LHGDN Overexpression of COX-2 gene in oral cancer is independent of stage of disease and degree of differentiation. 18356024 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.520 AlteredExpression group LHGDN Expression of NF-kappaB parallels COX-2 expression in oral precancer and cancer: association with smokeless tobacco. 17354234 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.520 Biomarker group CTD_human Elevated expression of cyclooxygenase (COX)-2 in oral squamous cell carcinoma--evidence for COX-2 induction by areca quid ingredients in oral keratinocytes. 12969226 2003
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 Biomarker group CTD_human Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin. 24224046 2013
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 Biomarker group RGD Diabetes enhances the expression of H-ras and suppresses the expression of EGFR leading to increased cell proliferation. 19283661 2009
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.340 Biomarker group CTD_human Promoter region hypermethylation and mRNA expression of MGMT and p16 genes in tissue and blood samples of human premalignant oral lesions and oral squamous cell carcinoma. 24991542 2014
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.340 AlteredExpression group LHGDN Immunohistochemical detection of p16INK4a in dysplastic lesions of the oral cavity. 16799478 2006
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.340 Biomarker group BEFREE The incidence of hypermethylation in oral tumor and adjacent mucosa for p16 gene was 66.7 and 50%, for DAPK was 68.3 and 60%, and MGMT gene was 51.7 and 26.7%, respectively. 14693237 2004
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.340 AlteredExpression group LHGDN Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer. 14719099 2004
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.340 PosttranslationalModification group LHGDN Epigenetic changes of tumor suppressor genes, P15, P16, VHL and P53 in oral cancer. 12684640 2003
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.320 Biomarker group CTD_human Promoter region hypermethylation and mRNA expression of MGMT and p16 genes in tissue and blood samples of human premalignant oral lesions and oral squamous cell carcinoma. 24991542 2014
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.320 AlteredExpression group LHGDN MGMT expression in oral precancerous and cancerous lesions: correlation with progression, nodal metastasis and poor prognosis. 16996781 2007
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.320 Biomarker group BEFREE The incidence of hypermethylation in oral tumor and adjacent mucosa for p16 gene was 66.7 and 50%, for DAPK was 68.3 and 60%, and MGMT gene was 51.7 and 26.7%, respectively. 14693237 2004
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.310 GeneticVariation group BEFREE Although it is unclear why different codon 12 alleles occur in different disease contexts and the complex interactions between tumor genotype and phenotype need clarification, on the basis of our results the presence of KRAS p.G12V/R favors the adenomatoid odontogenic tumor diagnosis in challenging oral neoplasm cases. 30643167 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.310 Biomarker group CTD_human Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. 19435901 2009
Entrez Id: 2810
Gene Symbol: SFN
SFN
0.310 PosttranslationalModification group LHGDN Methylation and intratumoural heterogeneity of 14-3-3 sigma in oral cancer. 17786341 2007