|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*08:01 allele interacted with smoking to increase MS risk.
|
31573825 |
2019 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the role of the two functional HLA-DR heterodimers, DR2a (DR alpha paired with the beta chain encoded by DRB5*0101) and DR2b (DR alpha paired with the beta chain encoded by DRB1*1501), that are coexpressed in the multiple sclerosis (MS)-associated haplotype HLA-DR15 Dw2, in presenting myelin basic protein (MBP) peptides to MBP-specific T cell lines (TCL).
|
9258250 |
1997 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
We did univariate and multivariable analyses to assess contributions of HLA-DRB1*15, Epstein-Barr virus, vitamin D status, MRI evidence of brain lesions, and CSF oligoclonal bands as determinants of multiple sclerosis.
|
21459044 |
2011 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
This is the first study performed to analyse the association of HLA-DRB1/DQB1 with susceptibility to MS in Slovakia.
|
26744784 |
2015 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genotyping of HLA-DRB1 and -DPB1 alleles was performed in 121 consecutive Japanese patients with clinically definite MS based on the Poser criteria and 125 healthy controls.
|
18952831 |
2008 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome wide differences of gene expression associated with HLA-DRB1 genotype in multiple sclerosis: a pilot study.
|
23477965 |
2013 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Results herein offer a model justifying the interaction between the major genetic (HLA-DRB*15) and environmental (vitamin D) factors associated with MS onset.
|
21664963 |
2011 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association between previous exposure to ultraviolet radiation (UVR), vitamin D status at inclusion in the study, and MS risk including the interaction of these factors with HLA-DRB1*15.
|
22289117 |
2012 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Scores were initially calculated using log odds ratio from the HLA-DRB1*1501 allele only, secondly using data from all MS-associated SNPs identified in the 2011 GWAS.
|
27802296 |
2016 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We found that, in addition to DR15, DR17 is positively associated with susceptibility to MS; that none of the HLA-DRB1 alleles influences course or outcome in MS; that carriers of DR15 are prone to MS development at an earlier age than noncarriers; and that differences in DR15 positivity rates, after stratification for diagnostic category and examination results, seem to reflect a gradient of phenocopy contamination, with rates increasing in proportion to the degree of clinical or paraclinical verification of the MS diagnosis.
|
10939572 |
2000 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
DRB1 1501 and C. pneumoniae infection confer CSF IgG abnormality, while DRB1 0405 and H. pylori infection are positively and negatively associated with CSF IgG abnormality-negative MS, respectively, suggesting that genetic and environmental factors differentially contribute to MS susceptibility according to the CSF IgG abnormality status.
|
24736746 |
2014 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Nevertheless, even for this major susceptibility allele, only a very small fraction of DRB1*1501carriers (<5%) are susceptible to getting MS and for only a minority of MS patients (∼41%) does this allele contribute to their susceptibility.
|
23272039 |
2012 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
To explore whether the relative rarity of MS in Malta might be the result of lower population frequencies of major histocompatibility complex susceptibility alleles, we genotyped the HLA-DRB1 locus in 77 Maltese-born patients (97% of the prevalent unrelated native cases) and 206 Maltese controls.
|
18057318 |
2008 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Moreover, we discovered no epistatic effect of the MBP gene on the HLA/MHC DRB1,DQB1, DPB1 loci or on alleles defined by D6S1683 marker found to be associated with MS in Sardinians.
|
12420096 |
2002 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A significant increase of DRB1*15 allele frequency (17.6% vs 8.4%, OR=2.67, 95% CI=1.36-5.23, P=0.004) and HLA-DRB1*15-DQB1*06 haplotype (8.8% vs 4.08%, OR=2.78, 95% CI=1.41-5.48, P=0.002) were observed in Moroccan MS patients.
|
23849771 |
2013 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two multiple sclerosis (MS)-associated genetic regions were modeled; DRB1 (a Class II molecule of the major histocompatibility complex) and MMEL1 (an endopeptidase that degrades both neuropeptides and β-amyloid).
|
24727690 |
2014 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cigarette smoking is a risk factor for multiple sclerosis (MS), and the risk is further multiplied for HLA-DRB1*15(+) smokers.
|
27339331 |
2016 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Taken together, TNFB2 allele was associated with the presence of MS independently of HLA-DRB1 in white patients and the TNFB2/B2 genotype was associated with increased TNF-α levels in white and brown patients, which could be an important genetic factor candidate for the susceptibility and pathogenesis of MS.
|
24696164 |
2014 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
On the whole, our results show a prominent role of the DRB1 locus (DRB1*1501 and/or DRB1*1503 alleles) in the immunodominant MBP 85-99 peptide presentation to genetically different MS patients and suggest a neutral role of the DQB1 encoded molecule in MS susceptibility.
|
12694585 |
2003 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
No major difference could be detected in the recognition of immunodominant hMBP peptides by TCL from DRB1*1501 positive or negative MS patients.
|
7679413 |
1993 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The evaluation of the HLA-DRB1 gene in the Brazilian population is of particular interest in evidencing the behavior of HLA-DRB1 alleles in a highly admixed population inserted in an environment of low MS prevalence.
|
17681614 |
2007 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Successes in advancing our appreciation of the roles of Epstein-Barr virus, vitamin D/UV and the HLA-DRB1 locus; and our greater understanding of these and related factors' modes of action in MS and other conditions, can be attributed in no small part to the work of generations of epidemiologists.
|
25767125 |
2015 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
These results indicate that the difference in risk association with MS of DRB1*1501 versus DRB1*1502 is not due to a lack of antigen presentation by DRB1*1502, at least for this set of myelin peptides, and suggest that other mechanisms involving DRB1*1501 may account for increased susceptibility to MS.
|
15372502 |
2004 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although significant associations with both HLA-DRB1 and HLA-DRB5 loci were present, HLA-DRB1*1503 was associated with MS in the absence of HLA-DRB5, providing evidence for HLA-DRB1 as the primary susceptibility gene.
|
18832704 |
2008 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The HLA-DRB1*1501 molecule may explain about 50% of MS cases and its role in the pathogenesis is supported by studies of transgenic mice.
|
18461312 |
2008 |