|
HLA-DQB1
|
0.400 |
Biomarker
|
disease |
BEFREE |
The effect observed was found to be strongest among the HLA-DQB1*0602-positive subjects, which implies genetic heterogeneity of MS. Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes (relative risk = 1.3, p = 0.002).
|
12590979 |
2003 |
|
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An association with MS was found for the HLA-DRB1*15 (odds ratio [OR] 2.60 [95% confidence interval (CI) 1.51-4.50]) and HLA-DQB1*06 (OR 1.97 [95% CI 1.18-3.29]) alleles, and for haplotype DRB1*15-DQB1*06 (OR 2.63 [95% CI 1.52-4.56]).
|
27797002 |
2017 |
|
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analyses of the HLA-DRB1*04 cohort in the absence of HLA-DRB1*15:01 haplotypes revealed that the HLA-DQB1*03:01:01:01~HLA-DQA1*03:03:01:01~HLA-DRB1*04:01:01:01SG~HLA-DRB4*01:03:01:01 haplotype was protective (OR = 0.64, p = 0.028), whereas the HLA-DQB1*03:02:01~HLA-DQA1*03:01:01~HLA-DRB1*04:01:01:01SG~HLA-DRB4*01:03:01:01 haplotype was associated with MS susceptibility (OR = 1.66, p = 4.9E-03).
|
29683085 |
2019 |
|
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To verify whether HLA-DQA and HLA-DQB genes differed between unrelated (MSU) and related (MSR) patients, and whether relapsing-remitting and chronic progressive forms of MS are immunogenetically distinct entities.
|
8442703 |
1993 |
|
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1*15 and HLA-DQB1*0602, nearly always located together on a small ancestral chromosome segment, are strongly MS-associated.
|
19380721 |
2009 |
|
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interactions between both HLA-DMB and the HLA-DRA promoter and other reported MS susceptibility loci were examined (TCRBV polymorphisms, HLA-DQA1 and HLA-DQB1).
|
10527398 |
1999 |
|
HLA-DQB1
|
0.400 |
Biomarker
|
disease |
BEFREE |
The HLA-DRB1*1501- and HLA-DQB1*0602-Tg mice (MHC-II(-/-)), and control non-HLA-DR15-relevant-Tg mice were immunized with a set of overlapping PLP peptides or with recombinant soluble PLP for induction of "humanized" MS-like disease, as well as for ex-vivo analysis of immunogenic/immunodominant HLA-restricted T-cell epitopes and associated cytokine secretion profile.
|
22316121 |
2012 |
|
HLA-DQB1
|
0.400 |
Biomarker
|
disease |
BEFREE |
The frequencies of HLA-DRB1 * 1501, HLA-DRB5 * 0101, HLA-DRB3 * 0301, and HLA-DQB1* 0602 were not as high in Korean children with multiple sclerosis as in western children.
|
15201511 |
2004 |
|
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The association of HLA-DRB1 and HLA-DQB1 alleles with genetic susceptibility to multiple sclerosis in the Slovak population.
|
26744784 |
2015 |
|
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk.
|
17845076 |
2007 |