HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
DQB1*0602 allele shows a strong association with multiple sclerosis in patients in Malaga, Spain.
|
15083289 |
2004 |
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It is striking that the common DQ6 allele HLA-DQB1(*)0602 is found in linkage disequilibrium with HLA-DRB1(*)1501, and this combination defines the HLA genotype associated with the development of multiple sclerosis.
|
14735143 |
2004 |
HLA-DQB1
|
0.400 |
Biomarker
|
disease |
BEFREE |
The frequencies of HLA-DRB1 * 1501, HLA-DRB5 * 0101, HLA-DRB3 * 0301, and HLA-DQB1* 0602 were not as high in Korean children with multiple sclerosis as in western children.
|
15201511 |
2004 |
HLA-DQB1
|
0.400 |
Biomarker
|
disease |
BEFREE |
The effect observed was found to be strongest among the HLA-DQB1*0602-positive subjects, which implies genetic heterogeneity of MS. Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes (relative risk = 1.3, p = 0.002).
|
12590979 |
2003 |
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although no significant differences were found between the patients and controls for the DRB1 and DQA1 alleles, the HLA-DQB1*0602 allele was positively associated with multiple sclerosis (45.0% vs. 17.0%, Pc=0.024, RR=3.31).
|
10599893 |
1999 |
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interactions between both HLA-DMB and the HLA-DRA promoter and other reported MS susceptibility loci were examined (TCRBV polymorphisms, HLA-DQA1 and HLA-DQB1).
|
10527398 |
1999 |
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To verify whether HLA-DQA and HLA-DQB genes differed between unrelated (MSU) and related (MSR) patients, and whether relapsing-remitting and chronic progressive forms of MS are immunogenetically distinct entities.
|
8442703 |
1993 |
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In contrast with a previous investigation of Norwegian MS patients, no association of MS with glutamine at position 34 of the HLA-DQ alpha chain or with defined sequences of the HLA-DQB1 gene was found.
|
1359021 |
1992 |
HLA-DQB1
|
0.400 |
Biomarker
|
disease |
BEFREE |
HLA-DQA1 and HLA-DQB1 genes may jointly determine susceptibility to develop multiple sclerosis.
|
2001977 |
1991 |
HLA-DQB1
|
0.400 |
Biomarker
|
disease |
CTD_human |
|
|
|