| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.360 | GeneticVariation | disease | BEFREE | The hereditary cardiomyopathic hamster of the UM-X7.1 strain is a particular experimental model of heart failure (HF) leading to early death in muscular dystrophy (dystrophin deficiency and sarcoglycan mutation) and heart disease (δ-sarcoglycan deficiency and dystrophin mutation) in human DMD. | 28727929 | 2017 | ||||
|
0.360 | Biomarker | disease | BEFREE | Here, we show that systemic delivery and muscle-specific overexpression of human MG53 gene by recombinant adeno-associated virus (AAV) vectors enhanced membrane repair, ameliorated pathology, and improved muscle and heart functions in δ-sarcoglycan (δ-SG)-deficient TO-2 hamsters, an animal model of MD and congestive heart failure. | 22314291 | 2012 | ||||
|
0.360 | Biomarker | disease | BEFREE | The alterations caused by the absence of delta-SG may be related to the pathogenesis of muscular dystrophy. | 19931597 | 2010 | ||||
|
0.360 | Biomarker | disease | BEFREE | In the present study, we demonstrate that muscular dystrophy is ameliorated in two animal models, dystrophin-deficient mdx mice and delta-sarcoglycan-deficient BIO14.6 hamsters by dominant-negative inhibition of the transient receptor potential cation channel, TRPV2, a principal candidate for Ca(2+)-entry pathways. | 19050039 | 2009 | ||||
|
0.360 | Biomarker | disease | MGD | Here we report that mice lacking (delta)-sarcoglycan developed muscular dystrophy and cardiomyopathy similar to mice lacking (gamma)-sarcoglycan. | 10862711 | 2000 | ||||
|
0.360 | Biomarker | disease | MGD | Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy. | 10481911 | 1999 | ||||
|
0.360 | Biomarker | disease | BEFREE | Importantly, muscle fibers expressing delta-sarcoglycan lack morphological markers of muscular dystrophy and exhibit restored plasma membrane integrity. | 9660967 | 1998 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | Absence of gamma-sarcoglycan (35 DAG) in autosomal recessive muscular dystrophy linked to chromosome 13q12. | 8641426 | 1996 | ||||
|
0.360 | Biomarker | disease | HPO |