Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 629
Gene Symbol: CFB
CFB
0.400 GeneticVariation disease GWASDB Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08. 23055271 2012
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.360 GeneticVariation disease BEFREE Sequential removal of human leukocyte antigen B (HLA-B) alleles when relative predispositional effects (RPEs) were looked for demonstrated that B*08 is the allele group with the largest contribution in the overall MG patients followed by B*39 and B*40. 14700596 2004
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.360 GeneticVariation disease BEFREE Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08. 23055271 2012
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.360 GeneticVariation disease BEFREE Overall distributions of HLA-B*61 and C*05 were more frequent in MG patients (7.4 vs. 2.0% and 14.8 vs. 6.8%, respectively) than in non-MG patients. 27802446 2017
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.360 GeneticVariation disease BEFREE The HLA-B*08 allele (12.9% in the controls), previously described associated with early onset adult MG, was most frequently observed in postpubertal onset MG (40.4%, P = 0.0002) but also increased among prepubertal onset MG (23.5%, P = 0.05). 29036181 2017
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.330 GeneticVariation disease BEFREE Since DQB1*03 and DPB1*0201 are not in linkage disequilibrium, both these alleles are supposed to be synergistically involved in disease development in early-onset female MG. 7749041 1994
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.330 GeneticVariation disease BEFREE These results indicate that both the DPB1*0201 allele and DR53 play key roles in the disease process of MG in early-onset females, and that the genetic background of Japanese females with early-onset MG is different from that of other patients with MG. 8469338 1993
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.330 GeneticVariation disease BEFREE HLA-DPB1 polymorphisms in patients with hyperthyroid Graves' disease and early onset myasthenia gravis. 8061167 1994
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.200 GeneticVariation disease BEFREE In contrast to findings in other autoimmune diseases, the distribution of the PTPN22 polymorphism in this population provides a susceptibility marker for AChR-MG. 25119822 2014
Entrez Id: 3117
Gene Symbol: HLA-DQA1
HLA-DQA1
0.200 GeneticVariation disease BEFREE Chinese Singaporean myasthenia gravis (MG) patients are associated with three HLA haplotypes: Cw1 B46 DRB1*0901 DQB1*0303 DQA1*03, DRB1*14 DRB3*0202 DQB1*0503 DQA1*0101 and DRB1*1202 DRB3*0301 DQB1*0301 DQA1*0601. 8508049 1993
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.200 GeneticVariation disease BEFREE This study provides novel information about HLA susceptibility alleles in Norwegian juvenile MG where HLA-DRB1*04:04 was associated with prepubertal onset. 29036181 2017
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.200 GeneticVariation disease BEFREE Among other MG subgroups and with less significance, DRB1*0101 DQA1*0101 DQB1*05 haplotype (P=0.016, OR=3.68) had positive association with pure ocular MG, and DRB1*03 DQA1*0501 DQB1*0201 haplotype (P=0.024) had negative association with thymomatous MG. 26671138 2015
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.200 GeneticVariation disease GWASCAT A genome-wide association study of myasthenia gravis. 25643325 2015
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.200 GeneticVariation disease BEFREE The meta-analysis showed that HLA DQB1*05, DRB1*14 and DRB1*16 were strongly associated with an increased risk of MuSK-MG (P < .0001), whereas HLA DQB*03 was less frequent in MuSK patients compared with healthy controls (P < .05). 29736936 2018
Entrez Id: 3117
Gene Symbol: HLA-DQA1
HLA-DQA1
0.200 GeneticVariation disease BEFREE Association of the AChRalpha-subunit gene (CHRNA), DQA1*0101, and the DR3 haplotype in myasthenia gravis. Evidence for a three-gene disease model in a subgroup of patients. 9237805 1997
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.200 GeneticVariation disease BEFREE The HLA DRB1*16-DQB1*05 (OR 2.9) haplotype was found to be associated with MuSK MG (P < 0.05). 25070808 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.200 GeneticVariation disease BEFREE Epigenetics, presume to be the mechanistic link between environmental and genetic risk factors in disease development, provides support for specific microRNAs associated with MG. Genetic studies have mainly pointed at specific HLA alleles implicated in MG susceptibility, however recently both TNFAIP3-interacting protein 1 (TNIP1) and tyrosine phosphatase non-receptor 22 (PTPN22) were indicated to be associated with MG in a GWAS study. 24361103 2014
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.200 GeneticVariation disease BEFREE We examined several autoantibodies and HLA-DRB1 genotyping in 260 Japanese MG patients.Sixty-two MG patients had thymoma. 21074862 2011
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.200 GeneticVariation disease BEFREE Myasthenia gravis (MG) is an autoimmune disorder which has previously been shown to be associated with polymorphisms of several autoimmune predisposing genes, including IL-1, PTPN22, TNF-α and the MHC. 20942939 2010
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.200 GeneticVariation disease BEFREE Furthermore, we performed low/high resolution typing of HLA-DRB1 and HLA-DQB1 alleles to detect associations of these loci with MG subtypes. 30741378 2019
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.200 GeneticVariation disease BEFREE The DRB1*14 haplotype was associated with thymic hyperplasia, younger onset patients, with high anti-AchR titres and with generalised MG. 8508049 1993
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.200 GeneticVariation disease GWASDB Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08. 23055271 2012
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.200 GeneticVariation disease BEFREE We conclude that the PTPN22(gain-of-function) variant biases towards MG in a subgroup of thymoma patients possibly by impeding central tolerance induction. 19693092 2009
Entrez Id: 3117
Gene Symbol: HLA-DQA1
HLA-DQA1
0.200 GeneticVariation disease GWASDB Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08. 23055271 2012
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.200 GeneticVariation disease BEFREE No statistically significant difference was observed in the overall prevalences of DRB1 and DQB1 alleles between MG patients and healthy controls, even when the patients and controls were stratified on the basis of their gender. 11535234 2001