Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE We analysed contact with physicians, hospital care and actual prescriptions for medication recommended in international guidelines, referring to beta-blockers, ACE inhibitors or angiotensin II receptor blockers, P2Y12-antiplatelet agents, acetylsalicylic acid and statins, one year after myocardial infarction. 31371116 2020
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE After induction of myocardial infarction (MI) by permanent ligation of the left coronary artery in BALB/c mice, the cardiac function, pulmonary congestion, disease biomarkers, and survival were evaluated using the angiotensin converting enzyme inhibitor enalapril or the loop diuretic furosemide. 30738210 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Clinical Outcomes at 2 Years Between Beta-Blockade with ACE Inhibitors or ARBs in Patients with AMI Who Underwent Successful PCI with DES: A Retrospective Analysis of 23,978 Patients in the Korea AMI Registry. 30788675 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE ACE inhibitor suppresses cardiac remodeling after myocardial infarction by regulating dendritic cells and AT<sub>2</sub> receptor-mediated mechanism in mice. 30974387 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers in hypertensive patients with myocardial infarction or heart failure: a systematic review and meta-analysis. 30948834 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Two days after MI, adult male CD1 mice were randomized to three groups, for four to eight weeks of oral treatment with vehicle (MI + vehicle), firibastat (150 mg/kg; MI + firibastat) or the angiotensin I converting enzyme inhibitor enalapril (1 mg/kg; MI + enalapril) as a positive control. 30599150 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE In patients with hypertension and hypertension with compelling indications, we found no difference in efficacy between ARBs and ACE inhibitors with regard to the surrogate endpoint of blood pressure and outcomes of all-cause mortality, cardiovascular mortality, myocardial infarction, heart failure, stroke, and end-stage renal disease. 29598869 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Angiotensin receptor neprilysin inhibition provides superior cardioprotection compared to angiotensin converting enzyme inhibition after experimental myocardial infarction. 29544929 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Carvedilol treatment was a strong predictor for being on target dose of BB at time of implant, as was treatment with angiotensin-converting enzyme inhibitors and/or spironolactone, no history of myocardial infarction, younger age and less pronounced heart failure symptoms. 28339659 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE However, the mortality of MI has declined dramatically over the past several decades because of advances in medicines (thrombolytic agents, antiplatelet drugs, beta blockers, and angiotensin converting enzyme inhibitors) and approaches to restore tissue perfusion (percutaneous coronary intervention and cardiopulmonary bypass). 30465493 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Medical therapy for HF after MI includes early (within 24 h) initiation of angiotensin-converting enzyme inhibitors and early (within 7 days) use of aldosterone antagonists. 29496021 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Neural mechanism of angiotensin-converting enzyme inhibitors in improving heart rate variability and sleep disturbance after myocardial infarction. 29859479 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE We identified indications for medication (statins, aspirin, ACE inhibitors, clopidogrel) recommended in UK National Institute for Clinical Excellence (NICE) guidance for CHD (high risk, stable angina, stable angina plus diabetes, unstable angina, and myocardial infarction) and measured the persistence of indicated medication (time from initiation to discontinuation) across quintiles of the Welsh Index of Multiple Deprivation, an area-based measure of socio-economic inequality, using Cox regression frailty models. 29522561 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Angiotensin-Converting Enzyme Inhibitors Provide Better Long-Term Survival Benefits to Patients With AMI Than Angiotensin II Receptor Blockers After Survival Hospital Discharge. 30130974 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE The ACE D allele is known to increase the risk of malignant ventricular arrhythmias and is also associated with increased QT dispersion after myocardial infarction and hypertension. 28575882 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 AlteredExpression disease BEFREE Additionally, the angiotensin-converting enzyme (ACE) activity in plasma was increased by 33% associated to histological myocardial necrosis. 28645882 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Multiple trials over the past several years have examined the effects of both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) in the treatment of left ventricular dysfunction, both acutely after myocardial infarction and in chronic heart failure. 28982370 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Age [OR = 1.1 (1.03-1.2), p = 0.002], previous MI [OR = 2.2 (1.1-4.4), p = 0.034], angiotensin-converting enzyme inhibitor or angiotensin receptor blocker [OR = 0.5 (0.3-0.9), p = 0.028], and LVEF < 35% [OR = 4.3 (1.9-9.5), p < 0.001] were associated with 1-year mortality. 29033508 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Blockade of the angiotensin-renin system, with angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs), has been shown to improve cardiac outcomes following myocardial infarction and delay progression of heart failure. 28166592 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE At discharge, women less frequently received ACE inhibitors (189 [81.1%] vs. 702 [85.8%], p=0.045) and presented more major adverse events (death, bleeding, infection, myocardial infarction, stent thrombosis or heart failure) during the first month after discharge (10.5% vs. 4.5%, p<0.001) and higher long-term mortality (hazard ratio [HR] 1.6, 95% CI 1.1-2.2). 27865662 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Angiotensin converting enzyme inhibitors (ACE-I), are beneficial both in heart failure with reduced ejection fraction (HF-REF) and after myocardial infarction (MI). 28577679 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 AlteredExpression disease BEFREE Randomized, active controlled parallel group trials were included if they compared CCBs with α-blockers, β-blockers, angiotensin II receptor blockers, angiotensin-converting enzyme inhibitors, or diuretics, had a follow-up of ≥6 months, and had assessments of blood pressure (BP) and CV events [all-cause death, CV death, major CV events (myocardial infarction, MI; congestive heart failure, CHF; stroke; and CV death), MI, stroke, or CHF] in patients with baseline systolic/diastolic BP ≥140/≥90 mm Hg with either concomitant previous stroke and/or CAD. 26588586 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Primary prevention of myocardial infarction with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in hypertensive patients with rheumatoid arthritis-A nationwide cohort study. 29216228 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE In this study, we aim to explore the association between ACE I/D polymorphisms and the risk of coronary HD (CHD), coronary artery disease (CAD), and myocardial infarction (MI). 26985916 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE We also wanted to examine possible environmental interaction of ACE gene with established cardiovascular risk factors in causation of MI. 26687160 2016