Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.550 | Biomarker | disease | BEFREE | Bone marrow mesenchymal stem cells overexpressing GATA-4 improve cardiac function following myocardial infarction. | 31090492 | 2019 | ||||
|
0.550 | AlteredExpression | disease | BEFREE | Exercise training at different intensities improved cardiac function and levels of stem cell and cardiomyocyte markers, and reduced infarct size. mRNA levels of GATA4, Nkx2.5 and c-Kit and protein expression of Nkx2.5 and c-Kit were significantly increased in all MI-exercise groups. | 30802510 | 2019 | ||||
|
0.550 | Biomarker | disease | BEFREE | Injection of GATA-4-BMSC exosomes in mice 48 h after MI increased cardiac function over the next 96 h; increased cardiac blood vessel density and number of c-kit-positive cells and decreased apoptotic cardiomyocyte cells were also observed. | 29899566 | 2018 | ||||
|
0.550 | Biomarker | disease | BEFREE | These results indicate significant potential for small molecules targeting GATA4-NKX2-5 interaction to promote myocardial repair after myocardial infarction and other cardiac injuries. | 29545582 | 2018 | ||||
|
0.550 | AlteredExpression | disease | BEFREE | Using NOD-SCID murine model of MI and human skeletal myoblast transplantation we were able to show that SkMC administration significantly affected gene expression profile (p<0.05) (NPPB, CTGF, GATA4, SERCA2a, PLB) of the heart ventricular tissue and this change was beneficial for the heart function. | 26457413 | 2016 | ||||
|
0.550 | Therapeutic | disease | RGD | Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling. | 23948075 | 2013 | ||||
|
0.550 | Therapeutic | disease | CTD_human | Myocardial infarction, caused by ligating the left anterior descending coronary artery, significantly decreased the DNA binding activity of GATA-4 at day 1, whereas at 2 weeks the GATA-4 DNA binding was significantly upregulated. | 20200331 | 2010 |