| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | miR-499 released during myocardial infarction causes endothelial injury by targeting α7-nAchR. | 31270949 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | NPY deletion increased miR-499 expression and decreased FoxO4 expression in MI <i>in vivo</i> and <i>in vitro</i>. | 31708788 | 2019 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The multivariate Cox proportional hazard analysis (relative risk [RR]; 95% confidence interval [CI]) revealed that miR-208b-3p (1.225; 1.092-1.375), miR-34a-5p (0.963; 0.935-0.992), and miR-499-5p (0.077; 0.025-0.239) were independently associated with risk of CVD/MI/CIE, as well as risk of each event. | 29350392 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | This is the first report to highlight the biological significance of this polymorphism on the maturation of miR-499-5p and its antiapoptotic role during MI. | 30102014 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | MiR-499 (for the inhibition of cardiomyocyte apoptosis) and plasmid encoding vascular endothelial growth factor (for the promotion of angiogenesis) are sequentially delivered for systemic treatment of MI. | 29920798 | 2018 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | These findings indicate that miR-499 rs3746444 and miR-146a rs2910164 may represent novel markers of MI susceptibility. | 24850191 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | Discrimination of MI was accurate for miR-208b (AUC = 0.82) and miR-499-5p (AUC = 0.79) but considerable lower than for Troponin T (AUC = 0.95). | 23448306 | 2013 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Our data reveal a role for miR-499 in regulating the mitochondrial fission machinery and we suggest that modulation of miR-499 levels may provide a therapeutic approach for treating myocardial infarction. | 21186368 | 2011 |