Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 646960
Gene Symbol: PRSS56
PRSS56
0.440 GeneticVariation disease GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
Entrez Id: 646960
Gene Symbol: PRSS56
PRSS56
0.440 GeneticVariation disease BEFREE Transcripts of Prss56, a gene associated with angle-closure glaucoma, posterior microphthalmia and myopia, were increased in Mfrprd6 eyes by 17-fold. 25357075 2014
Entrez Id: 646960
Gene Symbol: PRSS56
PRSS56
0.440 PosttranslationalModification disease BEFREE Finally, we demonstrate that genetic inactivation of Prss56 rescues axial elongation in a mouse model of myopia caused by a null mutation in Egr1. 29529029 2018
Entrez Id: 646960
Gene Symbol: PRSS56
PRSS56
0.440 GeneticVariation disease BEFREE Two recent large-scale genome-wide association studies identified significant associations between myopia and single nucleotide polymorphisms (SNPs) near the PRSS56, BMP3, KCNQ5, LAMA2, TOX, TJP2, RDH5, ZIC2, RASGRF1, GJD2, RBFOX1, and SHISA6 genes. 25587058 2015
Entrez Id: 646960
Gene Symbol: PRSS56
PRSS56
0.440 Biomarker disease CTD_human Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. 23396134 2013
Entrez Id: 646960
Gene Symbol: PRSS56
PRSS56
0.440 GeneticVariation disease BEFREE We also found evidence of association with spherical equivalent on 2q37.1 in PRSS56 at rs1550094 (MAF = 31%, β = -0.33, p = 1.7 × 10(-3)), a region previously associated with myopia. 27440996 2016
Entrez Id: 5923
Gene Symbol: RASGRF1
RASGRF1
0.430 Biomarker disease BEFREE Heritability of myopia and its relation with GDJ2 and RASGRF1 genes in Lithuania. 29793445 2018
Entrez Id: 5923
Gene Symbol: RASGRF1
RASGRF1
0.430 GeneticVariation disease GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
Entrez Id: 5923
Gene Symbol: RASGRF1
RASGRF1
0.430 Biomarker disease CTD_human Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. 23396134 2013
Entrez Id: 5923
Gene Symbol: RASGRF1
RASGRF1
0.430 AlteredExpression disease BEFREE The aim of this study was to investigate the messenger RNA (mRNA) expression of Rasgrf1 in the eyes of guinea pigs with induced myopia. 27723119 2017
Entrez Id: 5923
Gene Symbol: RASGRF1
RASGRF1
0.430 Biomarker disease BEFREE ZIC2 and RASGRF1 are susceptibility genes, not only for common myopia, but also for high myopia. 24150758 2013
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.420 Biomarker disease CTD_human Candidate gene and locus analysis of myopia. 17653045 2007
Entrez Id: 9997
Gene Symbol: SCO2
SCO2
0.420 GeneticVariation disease BEFREE The MYP6 locus is likely to contain susceptibility gene(s) for myopia, but none has yet been identified. 22792142 2012
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.420 GeneticVariation disease BEFREE Significant association was identified between five SNPs (rs1034762, rs1635529, rs1793933, rs3803183, and rs17122571) of the COL2A1 locus and high-grade myopia (P < 0.045, minimum (min) P = 0.008) and with myopia status set at <or=-0.50 or -0.75 D (min P = 0.004) in the Duke dataset. 19387081 2009
Entrez Id: 9997
Gene Symbol: SCO2
SCO2
0.420 Biomarker disease BEFREE No other disease-causing mutation was found in 101 extremely myopic Japanese patients, suggesting that SCO2 plays a limited role in Japanese extreme myopia. 27052445 2016
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.420 Biomarker disease HPO
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.420 GeneticVariation disease BEFREE Association studies have revealed that the rs1635529 polymorphism in the COL2A1 (collagen, type Ⅱ, α 1) gene may be a potential candidate for myopia development and may be associated with myopia in Caucasians. 21993774 2012
Entrez Id: 9997
Gene Symbol: SCO2
SCO2
0.420 GermlineCausalMutation disease ORPHANET Messenger RNA levels of SCO2 were significantly downregulated in myopic mouse retinae. 23643385 2013
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.420 CausalMutation disease CLINVAR
Entrez Id: 9997
Gene Symbol: SCO2
SCO2
0.420 Biomarker disease HPO
Entrez Id: 3908
Gene Symbol: LAMA2
LAMA2
0.410 GeneticVariation disease BEFREE Genetic studies have reported a significant association of the single nucleotide polymorphism (SNP) in the LAMA2 gene with myopia. 26984843 2016
Entrez Id: 3908
Gene Symbol: LAMA2
LAMA2
0.410 Biomarker disease CTD_human Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. 23396134 2013
Entrez Id: 5959
Gene Symbol: RDH5
RDH5
0.410 GeneticVariation disease GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
Entrez Id: 3908
Gene Symbol: LAMA2
LAMA2
0.410 GeneticVariation disease GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
Entrez Id: 5959
Gene Symbol: RDH5
RDH5
0.410 Biomarker disease CTD_human Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. 23396134 2013