Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 646960
Gene Symbol: PRSS56
PRSS56
0.440 GeneticVariation disease BEFREE Transcripts of Prss56, a gene associated with angle-closure glaucoma, posterior microphthalmia and myopia, were increased in Mfrprd6 eyes by 17-fold. 25357075 2014
Entrez Id: 646960
Gene Symbol: PRSS56
PRSS56
0.440 PosttranslationalModification disease BEFREE Finally, we demonstrate that genetic inactivation of Prss56 rescues axial elongation in a mouse model of myopia caused by a null mutation in Egr1. 29529029 2018
Entrez Id: 646960
Gene Symbol: PRSS56
PRSS56
0.440 GeneticVariation disease BEFREE Two recent large-scale genome-wide association studies identified significant associations between myopia and single nucleotide polymorphisms (SNPs) near the PRSS56, BMP3, KCNQ5, LAMA2, TOX, TJP2, RDH5, ZIC2, RASGRF1, GJD2, RBFOX1, and SHISA6 genes. 25587058 2015
Entrez Id: 646960
Gene Symbol: PRSS56
PRSS56
0.440 GeneticVariation disease BEFREE We also found evidence of association with spherical equivalent on 2q37.1 in PRSS56 at rs1550094 (MAF = 31%, β = -0.33, p = 1.7 × 10(-3)), a region previously associated with myopia. 27440996 2016
Entrez Id: 5923
Gene Symbol: RASGRF1
RASGRF1
0.430 Biomarker disease BEFREE Heritability of myopia and its relation with GDJ2 and RASGRF1 genes in Lithuania. 29793445 2018
Entrez Id: 5923
Gene Symbol: RASGRF1
RASGRF1
0.430 AlteredExpression disease BEFREE The aim of this study was to investigate the messenger RNA (mRNA) expression of Rasgrf1 in the eyes of guinea pigs with induced myopia. 27723119 2017
Entrez Id: 5923
Gene Symbol: RASGRF1
RASGRF1
0.430 Biomarker disease BEFREE ZIC2 and RASGRF1 are susceptibility genes, not only for common myopia, but also for high myopia. 24150758 2013
Entrez Id: 9997
Gene Symbol: SCO2
SCO2
0.420 GeneticVariation disease BEFREE The MYP6 locus is likely to contain susceptibility gene(s) for myopia, but none has yet been identified. 22792142 2012
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.420 GeneticVariation disease BEFREE Significant association was identified between five SNPs (rs1034762, rs1635529, rs1793933, rs3803183, and rs17122571) of the COL2A1 locus and high-grade myopia (P < 0.045, minimum (min) P = 0.008) and with myopia status set at <or=-0.50 or -0.75 D (min P = 0.004) in the Duke dataset. 19387081 2009
Entrez Id: 9997
Gene Symbol: SCO2
SCO2
0.420 Biomarker disease BEFREE No other disease-causing mutation was found in 101 extremely myopic Japanese patients, suggesting that SCO2 plays a limited role in Japanese extreme myopia. 27052445 2016
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.420 GeneticVariation disease BEFREE Association studies have revealed that the rs1635529 polymorphism in the COL2A1 (collagen, type Ⅱ, α 1) gene may be a potential candidate for myopia development and may be associated with myopia in Caucasians. 21993774 2012
Entrez Id: 3908
Gene Symbol: LAMA2
LAMA2
0.410 GeneticVariation disease BEFREE Genetic studies have reported a significant association of the single nucleotide polymorphism (SNP) in the LAMA2 gene with myopia. 26984843 2016
Entrez Id: 5959
Gene Symbol: RDH5
RDH5
0.410 Biomarker disease BEFREE Although two previous studies suggested strong associations between PRSS56, LAMA2, TOX, and RDH5 and myopia, we could not replicate these results. 25335978 2014
Entrez Id: 57369
Gene Symbol: GJD2
GJD2
0.340 Biomarker disease BEFREE This study aimed to assess heritability of myopia in Lithuania and evaluate both genes GJD2 (Gap Junction Protein, Delta 2) and RASGRF1 (RAS protein-specific guanine nucleotide-releasing factor 1) relation with myopia. 29793445 2018
Entrez Id: 57369
Gene Symbol: GJD2
GJD2
0.340 GeneticVariation disease BEFREE We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10(-13)) and corneal curvature (Pmeta=2.9 × 10(-40)) and confirm the previously reported association between GJD2 and myopia. 25823570 2015
Entrez Id: 57369
Gene Symbol: GJD2
GJD2
0.340 Biomarker disease BEFREE Decreased expression of gap junction delta-2 (GJD2) messenger RNA and connexin 36 protein in form-deprivation myopia of guinea pigs. 31283648 2019
Entrez Id: 57369
Gene Symbol: GJD2
GJD2
0.340 GeneticVariation disease BEFREE Two recent large-scale genome-wide association studies identified significant associations between myopia and single nucleotide polymorphisms (SNPs) near the PRSS56, BMP3, KCNQ5, LAMA2, TOX, TJP2, RDH5, ZIC2, RASGRF1, GJD2, RBFOX1, and SHISA6 genes. 25587058 2015
Entrez Id: 650
Gene Symbol: BMP2
BMP2
0.320 Biomarker disease BEFREE To clarify the role of bone morphogenetic proteins (BMP-2,-4,-5) in sclera remodeling during myopia induction and their effect on sclera fibroblasts in cell culture. 21403850 2011
Entrez Id: 650
Gene Symbol: BMP2
BMP2
0.320 Biomarker disease BEFREE Given BMP2 as a potential regulator involved in myopia development, we investigate whether gene BMP2-inducible kinase (BMP2K, BIKe), whose expression is up-regulated during BMP2-induced osteoblast differentiation, contributes to susceptibility of high myopia. 19927351 2009
Entrez Id: 55214
Gene Symbol: P3H2
P3H2
0.310 Biomarker disease BEFREE In this study, differences in prolyl 3-hydroxylation were screened in eye tissues from P3h2-null (P3h2(n/n)) and wild-type mice to seek tissue-specific effects due the lack of P3H2 activity on post-translational collagen chemistry that could explain myopia. 25645914 2015
Entrez Id: 4043
Gene Symbol: LRPAP1
LRPAP1
0.310 GeneticVariation disease BEFREE We have identified Mendelian forms of myopia in four consanguineous families and implemented exome/autozygome analysis to identify homozygous truncating variants in LRPAP1 and CTSH as the likely causal mutations. 23830514 2013
Entrez Id: 135
Gene Symbol: ADORA2A
ADORA2A
0.210 GeneticVariation disease BEFREE Genetic deletion of the adenosine A2A receptor confers postnatal development of relative myopia in mice. 20484596 2010
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.170 GeneticVariation disease BEFREE We investigated whether the IGF-1 single nucleotide polymorphisms (SNPs) rs6214, rs10860860, and rs2946834 are associated with HM (≤-6.0 diopters [D]) and any myopia (≤-0.5 D) phenotype in Polish families. 21976954 2011
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.170 GeneticVariation disease BEFREE The polymorphism of rs12423791 in IGF-1 may be associated with extreme myopia in the Chinese population and should be investigated further. 22509095 2012
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.170 Biomarker disease BEFREE Additionally, overexpression of MMP-2 mediated by IGF-1/STAT3 pathway in sclera might promote the formation of myopia. 29771404 2018