Peripapillary border tissue of the choroid (PBT-C) and PBT-S as continuation of the optic nerve pia mater are distinct structures, with PBT-C remodelling during myopic axial elongation and PBT-S being mostly independent of axial elongation.
By using bioinformatics analysis, we identified six well-known myopia-associated genes that are potential targets of five myopia-specific miRNAs (has-miR-582-3p, has-miR-17-5p, has-miR-885-3p, has-miR-19b-3p, and has-miR-450b-5p).
A locus encompassing the genes PIK3CG and PRKAR2B was genome-wide significantly associated with myopia susceptibility in chicks (lead variant rs317386235, P = 9.54e-08).
The AIs of all retinal layers were larger in myopes than in hyperopes and emmetropes in the perifoveal region (all p < 0.001), and the AIs became even larger in the GCL+ layer and neural retina in children with a higher degree of myopia.
To evaluate the ability of the PDI Check (PDI Check LLC, Anchorage, AK) near vision screening game to assess monocular acuity, stereopsis, suppression, and color.
Guinea pigs in the REC groups also wore the facemask for 21 days to induce myopia; then, the facemask was removed, and the eye was re-exposed to the normal environment for 12 hours (REC ½ group), 1 day (REC 1 group), 2 days (REC 2 group), and 7 days (REC 7 group).
The prospective study was conducted to analyze patients who underwent SMILE for correction of myopia and myopic astigmatism ≥2.5D (high astigmatism group, HA) at the ophthalmology department, Eye and ENT hospital, Shanghai, China..
Guinea pigs in the REC groups also wore the facemask for 21 days to induce myopia; then, the facemask was removed, and the eye was re-exposed to the normal environment for 12 hours (REC ½ group), 1 day (REC 1 group), 2 days (REC 2 group), and 7 days (REC 7 group).
Taken together, the results suggest that mutant HS6ST2 is possibly involved in the development of myopia and cognitive impairment, characteristics of the probands reported here.
The AIs of all retinal layers were larger in myopes than in hyperopes and emmetropes in the perifoveal region (all p < 0.001), and the AIs became even larger in the GCL+ layer and neural retina in children with a higher degree of myopia.
Using the LDSC method, we found a genetic correlation only between myopia and disc area (genetic correlation [RhoG] = -0.12, P = 1.8 × 10-3), supporting the findings of the PRS approach.
To evaluate the ability of the PDI Check (PDI Check LLC, Anchorage, AK) near vision screening game to assess monocular acuity, stereopsis, suppression, and color.
The AIs of all retinal layers were larger in myopes than in hyperopes and emmetropes in the perifoveal region (all p < 0.001), and the AIs became even larger in the GCL+ layer and neural retina in children with a higher degree of myopia.
AQP-1 protein expression was significantly associated with CT (<i>p</i> = .001) in all groups; however, there was a significant negative correlation (<i>p</i> = .029) between AQP-1 protein expression and axial length in the REC groups.<b>Conclusions</b>: AQP-1 protein expression in the choroid was upregulated following recovery of FD myopia in guinea pigs, and these changes correlated with alterations in CT and axial length.
To evaluate the ability of the PDI Check (PDI Check LLC, Anchorage, AK) near vision screening game to assess monocular acuity, stereopsis, suppression, and color.
In mice, retinal-specific knockout of the clock gene Bmal1 induces myopia and elongates the vitreous chamber, the optical compartment separating the lens and the retina.
A locus encompassing the genes PIK3CG and PRKAR2B was genome-wide significantly associated with myopia susceptibility in chicks (lead variant rs317386235, P = 9.54e-08).
AQP-1 protein expression was significantly associated with CT (<i>p</i> = .001) in all groups; however, there was a significant negative correlation (<i>p</i> = .029) between AQP-1 protein expression and axial length in the REC groups.<b>Conclusions</b>: AQP-1 protein expression in the choroid was upregulated following recovery of FD myopia in guinea pigs, and these changes correlated with alterations in CT and axial length.
This article reports an innovative transdisciplinary methodology to down scale Climate Change scenarii to river basin level with a special focus on the development of climate change narrative under SSP5-RCP8.5 combination called Myopic scenario and SSP1-RCP4.5 combination called Sustainable scenario.