|
HLA-DQA1
|
0.200 |
Biomarker
|
disease |
BEFREE |
HLA-DQB1*0602 forms a heterodimer with HLA-DQA1*0102 and may act as an antigen presenter to the T cell receptors, resulting in narcolepsy susceptibility.
|
28108192 |
2018 |
|
HLA-DQA1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Both DQA1 and DQB1 influence narcolepsy risk.
|
25325462 |
2015 |
|
HLA-DQA1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To study the impact of the expression of the HLA-DQ0602 dimer on narcolepsy susceptibility, 248 Dutch narcolepsy patients and 1272 Dutch control subjects, all of them positive for DQB1*06:02 (heterozygous and homozygous), were HLA-genotyped with attention not only to DQB1 but also to DQA1*01:02.
|
25277311 |
2015 |
|
HLA-DQA1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Application of high-resolution PCR-SSP, a reliable and simple method, for both allele- and locus-specific HLA typing of DRB1*15/16, DQA1, and DQB1 would be useful for characterizing clinical status among subjects with narcolepsy.
|
22259780 |
2012 |
|
HLA-DQA1
|
0.200 |
Biomarker
|
disease |
BEFREE |
The results are also in line with a previously proposed 'HLA-DQ allelic competition model' that involves competition between non-DQA1*01:02, non-DQB1*06:02 'competent' (able to dimerize together) DQ1 alleles and the major DQα*01:02/ DQβ*06:02 narcolepsy heterodimer to reduce susceptibility.
|
22862152 |
2012 |
|
HLA-DQA1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association database developed in the Japanese Integrated Database Project.
|
19629137 |
2009 |
|
HLA-DQA1
|
0.200 |
Biomarker
|
disease |
BEFREE |
The HLA class II region genes DQB1*0602 and DQA1*0102 are currently the best genetic predictors for narcolepsy in humans (1(.
|
12097985 |
2002 |
|
HLA-DQA1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Narcolepsy is a neurological disorder known to be tightly associated with HLA-DQA1*0102 and DQB1*0602.
|
9459509 |
1998 |
|
HLA-DQA1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Research in human narcolepsy has led to the identification of specific HLA alleles (DQB1*0602 and DQA1*0102) that predispose to the disorder.
|
9582188 |
1998 |
|
HLA-DQA1
|
0.200 |
Biomarker
|
disease |
BEFREE |
We conclude that HLA DQA1*0102 and DQB1*0602 are the most likely primary candidate susceptibility genes for narcolepsy in the HLA class II region.
|
9151385 |
1997 |
|
HLA-DQA1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The haplotype DRB1*1501-DRB5*0101-DQA1*0102-DQB1*0602 was found to be significantly associated with the disease, while the haplotype DRB1*0701-DRB4*01-DQA1*0201-DQB1*02 might confer a slight protective effect against narcolepsy.
|
9534039 |
1997 |
|
HLA-DQA1
|
0.200 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that DQB1*0602/DQA1*0102 is the best marker for narcolepsy across all ethnic groups.
|
7701202 |
1994 |
|
HLA-DQA1
|
0.200 |
Biomarker
|
disease |
BEFREE |
None of the patients was DQB1-0602 or DQA1-0102 positive, thus proving that, in caucasians, DQB1-0602 and DQA1-0102 (DQw1) are not prerequisites for the diagnosis of narcolepsy.
|
1455124 |
1992 |