Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE TGF-β1 Induces Epithelial-Mesenchymal Transition of Chronic Sinusitis with Nasal Polyps through MicroRNA-21. 30982052 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE The current study suggests that the upregulation of TGF-β1 may be associated with the downregulation of miR-663 in nasal polyposis in children. miR-663 may have regulatory effects on the pathogenesis of nasal polyposis by regulating TGF-β1 and may be developed as a genetic marker of nasal polyposis in children. 29849780 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE To investigate the potential role of vitamin D (1,25(OH)<sub>2</sub>D<sub>3</sub>) in preventing the development of nasal polyps, we examined the effect of vitamin D on myofibroblast differentiation and extracellular matrix (ECM) production in TGF-β1-induced nasal polyp-derived fibroblasts (NPDFs) and elucidated the mechanisms underlying its inhibitory effect. 28779150 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE Doxycycline inhibits TGF-β1-induced extracellular matrix production in nasal polyp-derived fibroblasts. 26575862 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease BEFREE Messenger RNA levels of TGF-β1, TGF-β receptor I, and Smad3 in CRSwNP ethmoid bone tissues were significantly higher than those in ethmoid bone tissues of patients with CRSsNP and the controls. 26265084 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease BEFREE IL-4 and IL-13 levels were increased in CRSwNP, while IL-4, IFN-γ, TNF-α, and TGF-β1 levels were increased in CRSsNP. 23375208 2013
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE The levels of IL-6, IL-2, pSTAT3, pSTAT5, SOCS3, RORc, Foxp3, IL-17A, and TGF-β1 were measured in patients with atopic NP, patients with nonatopic NP, and controls. 22959364 2013
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE After organ culture, nasal polyps were stimulated with TGF-beta1 and then treated with TSA. 23406592 2013
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE Our conclusions were that that VEGFA and TGFbeta1 participate significantly in the formation of NPs, whereas FGF2 and IGF1 are implicated in nasal polyposis to a lesser, but still significant, extent. 18202785 2008
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease LHGDN Possible role of transforming growth factor beta and interleukin-4 in the up-regulation of CLC-2 and CLC-3 in chronic rhinosinusitis. 17882904 2007
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE Eosinophil-derived TGF-beta1 may contribute, at least in part, to the tissue remodeling in NPs. 17181107 2007
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease BEFREE We believe that the high expression of TGF-beta1 in inflammatory mucosa compared with the low expression in polyps may reflect an important role in the inhibitory mechanisms of nasal polyposis. 17424886 2007
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease BEFREE TGF-beta1 transcriptional activity was accompanied by TGF-beta2 transcriptional activity in nasal polyps. 18059253 2007
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease LHGDN Finally, we showed that the effects of TGF-beta 1 on ion transports could be reversed after 48-h removal of TGF-beta1 in NP cultures. 15361357 2005
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE Finally, we showed that the effects of TGF-beta 1 on ion transports could be reversed after 48-h removal of TGF-beta1 in NP cultures. 15361357 2005
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease LHGDN The aim of this study was to evaluate the role of MMPs and tissue-inhibitor of metalloproteinase-1 (TIMP-1) in association with TGF-beta1, eosinophils and mast cell activation in nasal polyp tissue. 12589095 2003