Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 246
Gene Symbol: ALOX15
ALOX15
0.410 GeneticVariation disease BEFREE Most notably, a missense variant in ALOX15 that causes a p.Thr560Met alteration in arachidonate 15-lipoxygenase (15-LO) confers large genome-wide significant protection against NP (P = 8.0 × 10<sup>-27</sup>, odds ratio = 0.32; 95% confidence interval = 0.26, 0.39) and CRS (P = 1.1 × 10<sup>-8</sup>, odds ratio = 0.64; 95% confidence interval = 0.55, 0.75). p.Thr560Met, carried by around 1 in 20 Europeans, was previously shown to cause near total loss of 15-LO enzymatic activity. 30643255 2019
Entrez Id: 246
Gene Symbol: ALOX15
ALOX15
0.410 GeneticVariation disease GWASCAT Most notably, a missense variant in ALOX15 that causes a p.Thr560Met alteration in arachidonate 15-lipoxygenase (15-LO) confers large genome-wide significant protection against NP (P = 8.0 × 10<sup>-27</sup>, odds ratio = 0.32; 95% confidence interval = 0.26, 0.39) and CRS (P = 1.1 × 10<sup>-8</sup>, odds ratio = 0.64; 95% confidence interval = 0.55, 0.75). p.Thr560Met, carried by around 1 in 20 Europeans, was previously shown to cause near total loss of 15-LO enzymatic activity. 30643255 2019
Entrez Id: 246
Gene Symbol: ALOX15
ALOX15
0.410 Biomarker disease CTD_human Most notably, a missense variant in ALOX15 that causes a p.Thr560Met alteration in arachidonate 15-lipoxygenase (15-LO) confers large genome-wide significant protection against NP (P = 8.0 × 10<sup>-27</sup>, odds ratio = 0.32; 95% confidence interval = 0.26, 0.39) and CRS (P = 1.1 × 10<sup>-8</sup>, odds ratio = 0.64; 95% confidence interval = 0.55, 0.75). p.Thr560Met, carried by around 1 in 20 Europeans, was previously shown to cause near total loss of 15-LO enzymatic activity. 30643255 2019
Entrez Id: 4254
Gene Symbol: KITLG
KITLG
0.320 Biomarker disease CTD_human For the whole group of patients, the number of polypectomies correlated with expression of SCF mRNA (r = 0.62; P < 0.005), SCF protein in the NPECs supernatants (r = 0.39; P < 0.05) and with density of mast cells in epithelial layer (r = 0.37; P < 0.05) and stromal layer (r = 0.5; P < 0.01) of nasal polyps. 15813808 2005
Entrez Id: 4254
Gene Symbol: KITLG
KITLG
0.320 Biomarker disease BEFREE For the whole group of patients, the number of polypectomies correlated with expression of SCF mRNA (r = 0.62; P < 0.005), SCF protein in the NPECs supernatants (r = 0.39; P < 0.05) and with density of mast cells in epithelial layer (r = 0.37; P < 0.05) and stromal layer (r = 0.5; P < 0.01) of nasal polyps. 15813808 2005
Entrez Id: 4254
Gene Symbol: KITLG
KITLG
0.320 Biomarker disease BEFREE Northern blot analyses for messenger RNA and ELISA for biologically active SCF protein from cultured Np epithelial cells and fibroblasts were performed. 9314353 1997
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.130 GeneticVariation disease GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.130 AlteredExpression disease BEFREE In CRSsNP, we unexpectedly found simultaneous upregulation of T-bet and GATA3 that is currently unexplained; however, it might originate from activated CD8+ cells, abundant in nasal mucosa of CRSsNP patients. 31326962 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.130 AlteredExpression disease BEFREE The mRNA expression of GATA3 was increased in CRSwNP patients while mRNA expression of Ror-γt was elevated in CRSsNP patients. 30002685 2018
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.130 AlteredExpression disease BEFREE Compared with controls, mRNA levels corresponding to T-reg genes were significantly increased in NP (FOXP3, TGFB1, IL10, SMAD3, IL2RA, and JAK3), but transcription factors associated with Th2 (GATA3) or Th17 responses (RORc) were significantly reduced. 22462754 2012
Entrez Id: 3117
Gene Symbol: HLA-DQA1
HLA-DQA1
0.120 GeneticVariation disease GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255 2019
Entrez Id: 3117
Gene Symbol: HLA-DQA1
HLA-DQA1
0.120 Biomarker disease BEFREE DQA1 and DQB1 association and nasal polyposis. 16890076 2006
Entrez Id: 3117
Gene Symbol: HLA-DQA1
HLA-DQA1
0.120 GeneticVariation disease BEFREE This study investigated whether there is an association between HLA-DRB1, -DQA1, and -DQB1 alleles and developing nasal polyposis. 10718431 2000
Entrez Id: 51364
Gene Symbol: ZMYND10
ZMYND10
0.110 Biomarker disease BEFREE To evaluate the efficacy and safety of EDS-FLU versus EDS-placebo in patients with nasal polyps (NP). 30477309 2019
Entrez Id: 221421
Gene Symbol: RSPH9
RSPH9
0.110 AlteredExpression disease BEFREE The total fluorescence intensity of <i>CP110</i> and <i>FOXJ1</i> was significantly higher in NPs and correlated positively with expression pattern scores of <i>RSPH1</i>, <i>RSPH4A</i>, <i>RSPH9,</i> and <i>DNAH5</i>. 31798623 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.110 GeneticVariation disease GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255 2019
Entrez Id: 1767
Gene Symbol: DNAH5
DNAH5
0.110 Biomarker disease BEFREE Based on our DNAH5 scoring system, the median (1st and 3rd quartile) score was 0.3 (0.2 and 0.4) for samples from controls, and 1.1 (0.6 and 1.6) for samples from NPs in paraffin specimens (P < 0.001). 29148098 2018
Entrez Id: 5732
Gene Symbol: PTGER2
PTGER2
0.110 AlteredExpression disease BEFREE These studies suggest that the EP2 promotor is under epigenetic control, and one explanation for PGE2 resistance in AERD is an epigenetically mediated reduction of EP2 receptor expression, which could contribute to the refractory nasal polyposis typically observed in this syndrome. 26051534 2016
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.110 Biomarker disease BEFREE The HLA-B*07 and -Cw*12 alleles were found to be significantly higher in the NP patients compared with the control group, whereas the HLA-B*57 and HLA-Cw*04 alleles were significantly lower (P < 0.05). 18922348 2008
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.110 GeneticVariation disease BEFREE Germline STK11/LKB1 mutations were identified in all patients with PJS and nasal polyposis. 16775120 2007
Entrez Id: 221421
Gene Symbol: RSPH9
RSPH9
0.110 Biomarker disease HPO
Entrez Id: 51364
Gene Symbol: ZMYND10
ZMYND10
0.110 Biomarker disease HPO
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.110 Biomarker disease HPO
Entrez Id: 5732
Gene Symbol: PTGER2
PTGER2
0.110 Biomarker disease HPO
Entrez Id: 1767
Gene Symbol: DNAH5
DNAH5
0.110 Biomarker disease HPO