Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5329
Gene Symbol: PLAUR
PLAUR 		0.500 Biomarker phenotype CTD_human Nicotine stimulates urokinase-type plasminogen activator receptor expression and cell invasiveness through mitogen-activated protein kinase and reactive oxygen species signaling in ECV304 endothelial cells. 22261521 2012
Entrez Id: 5329
Gene Symbol: PLAUR
PLAUR 		0.500 Biomarker phenotype RGD Decreased expression of intercellular adhesion molecule-1 (ICAM-1) and urokinase-type plasminogen activator receptor (uPAR) is associated with tumor cell spreading in vivo. 12198772 2002
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		0.310 Biomarker phenotype CTD_human AKT signaling is involved in fucoidan-induced inhibition of growth and migration of human bladder cancer cells. 24333868 2014
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		0.310 Biomarker phenotype CTD_human Platycodin D inhibits migration, invasion, and growth of MDA-MB-231 human breast cancer cells via suppression of EGFR-mediated Akt and MAPK pathways. 23867902 2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		0.310 Biomarker phenotype CTD_human Osthole inhibits the invasive ability of human lung adenocarcinoma cells via suppression of NF-κB-mediated matrix metalloproteinase-9 expression. 22503731 2012
Entrez Id: 4312
Gene Symbol: MMP1
MMP1 		0.310 Biomarker phenotype CTD_human Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. 22580338 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		0.310 Biomarker phenotype CTD_human Metallothionein-2A overexpression increases the expression of matrix metalloproteinase-9 and invasion of breast cancer cells. 21187089 2011
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		0.310 Biomarker phenotype CTD_human Suppression of Heregulin-β1/HER2-Modulated Invasive and Aggressive Phenotype of Breast Carcinoma by Pterostilbene via Inhibition of Matrix Metalloproteinase-9, p38 Kinase Cascade and Akt Activation. 19617202 2011
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		0.310 Biomarker phenotype CTD_human Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9. 19700239 2010
Entrez Id: 1116
Gene Symbol: CHI3L1
CHI3L1 		0.310 Biomarker phenotype CTD_human Resveratrol represses YKL-40 expression in human glioma U87 cells. 21029458 2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		0.310 Biomarker phenotype CTD_human Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. 20188714 2010
Entrez Id: 1116
Gene Symbol: CHI3L1
CHI3L1 		0.310 Biomarker phenotype LHGDN Expression of YKL-40 by peritumoral macrophages in human small cell lung cancer. 15829322 2005
Entrez Id: 4312
Gene Symbol: MMP1
MMP1 		0.310 AlteredExpression phenotype LHGDN Stromal expression of invasion-promoting, matrix-degrading proteases MMP-1 and -9 and the Ets 1 transcription factor in HNPCC carcinomas and sporadic colorectal cancers. 12949792 2003
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		0.310 AlteredExpression phenotype LHGDN Stromal expression of invasion-promoting, matrix-degrading proteases MMP-1 and -9 and the Ets 1 transcription factor in HNPCC carcinomas and sporadic colorectal cancers. 12949792 2003
Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1 		0.310 Biomarker phenotype LHGDN Staurosporine enhances the expression of tissue inhibitor of metalloproteinase-1 in human prostate cancer cells. 12150976 2002
Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1 		0.310 Therapeutic phenotype CTD_human Suppression of invasion by inducible expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in B16-F10 melanoma cells. 1318976 1992
Entrez Id: 4853
Gene Symbol: NOTCH2
NOTCH2 		0.300 Biomarker phenotype CTD_human Long Noncoding RNA (lncRNA) MIR22HG Suppresses Gastric Cancer Progression through Attenuating NOTCH2 Signaling. 30670679 2019
Entrez Id: 100126335
Gene Symbol: MIR543
MIR543 		0.300 Therapeutic phenotype CTD_human miR-543 inhibites cervical cancer growth and metastasis by targeting TRPM7. 30710498 2019
Entrez Id: 54822
Gene Symbol: TRPM7
TRPM7 		0.300 Biomarker phenotype CTD_human miR-543 inhibites cervical cancer growth and metastasis by targeting TRPM7. 30710498 2019
Entrez Id: 693124
Gene Symbol: MIR532
MIR532 		0.300 Biomarker phenotype CTD_human Downregulation of microRNA-532-5p promotes the proliferation and invasion of bladder cancer cells through promotion of HMGB3/Wnt/β-catenin signaling. 30639441 2019
Entrez Id: 406966
Gene Symbol: MIR191
MIR191 		0.300 Biomarker phenotype CTD_human MicroRNA-191, regulated by HIF-2α, is involved in EMT and acquisition of a stem cell-like phenotype in arsenite-transformed human liver epithelial cells. 29277653 2018
Entrez Id: 100126343
Gene Symbol: MIR874
MIR874 		0.300 Therapeutic phenotype CTD_human Upregulation of miR-874-3p and miR-874-5p inhibits epithelial ovarian cancer malignancy via SIK2. 30004169 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A 		0.300 Biomarker phenotype CTD_human Involvement of HIF-1α-regulated miR-21, acting via the Akt/NF-κB pathway, in malignant transformation of HBE cells induced by cigarette smoke extract. 29501572 2018
Entrez Id: 92140
Gene Symbol: MTDH
MTDH 		0.300 Biomarker phenotype CTD_human MicroRNA-1271 suppresses the proliferation and invasion of colorectal cancer cells by regulating metadherin/Wnt signaling. 29315995 2018
Entrez Id: 406991
Gene Symbol: MIR21
MIR21 		0.300 Biomarker phenotype CTD_human Involvement of HIF-1α-regulated miR-21, acting via the Akt/NF-κB pathway, in malignant transformation of HBE cells induced by cigarette smoke extract. 29501572 2018