Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 Biomarker phenotype BEFREE The identification of osteopontin as a metastasis-related gene product in a rodent mammary tumour model. 8700559 1996
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 GeneticVariation phenotype BEFREE As part of our ongoing studies to characterize molecular alterations in a well-defined series of surgically resected esophageal cancers, we examined the expression of 2 ras-regulated genes, whose products (osteopontin and cathepsin L) previously were shown to be associated with tumor invasion and metastasis. 9311587 1997
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 Biomarker phenotype BEFREE This study suggests that breast cancer cells that have metastasized to bone may have a survival advantage resulting from interaction of alphavbeta3 on these cells with the bone protein osteopontin. 11078811 2000
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 Biomarker phenotype BEFREE Two categories of genes are presented--metastasis activator (ras, MEK1, mta1, proteinases, adhesion molecules, chemoattractants/receptors, autotaxin, PKC, S100A4, RhoC, osteopontin) and metastasis suppressor (Nm23, E-cadherin, TIMPs, KiSS1, Kai1, Maspin, MKK4, BRMS1). 12013533 2001
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 Biomarker phenotype BEFREE Osteopontin (OPN) is a phosphorylated glycoprotein with diverse functions including cancer development, progression and metastasis. 11520606 2001
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 AlteredExpression phenotype BEFREE Contrasting expression of thrombospondin-1 and osteopontin correlates with absence or presence of metastatic phenotype in an isogenic model of spontaneous human breast cancer metastasis. 11801541 2002
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 AlteredExpression phenotype LHGDN Contrasting expression of thrombospondin-1 and osteopontin correlates with absence or presence of metastatic phenotype in an isogenic model of spontaneous human breast cancer metastasis. 11801541 2002
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 AlteredExpression phenotype BEFREE Although OPN overexpression was not related to vascular invasion or intrahepatic metastasis, OPN was suggested to play a role in HCC, especially in cancer-stromal interactions. 11940202 2002
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 AlteredExpression phenotype BEFREE Constitutive expression of OPN in itself exerted partial invasiveness in vitro, but its expression itself was not sufficient to initiate tumor growth or metastasis formation in vivo. 12915117 2003
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 AlteredExpression phenotype BEFREE Using a panel of genes identified by suppression subtractive hybridization of cDNAs from individual primary tumours and a metastasis, some cDNAs were found to exhibit a differential pattern of expression associated with the expression of S100A4 protein (including osteopontin, S100A9, claudin 2 and several Expressed Sequence Tags sequences). 14632631 2003
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 GeneticVariation phenotype BEFREE The OPN overexpression was associated closely with alpha-fetoprotein elevation (P = 0.001), p53 mutation (P = 0.021), larger tumors (P = 0.002), high-grade HCC (P < 0.001), late-stage HCC (P < 0.001), early tumor recurrence and/or metastasis (P = 0.003), and a lower 10-year survival rate (P = 0.00013). 12833464 2003
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 Biomarker phenotype BEFREE Although expression of other genes may also be regulated by these transcription factors, evidence suggests that often OPN alone can stimulate metastasis. 12650610 2003
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 Biomarker phenotype BEFREE The following review will discuss the molecular structure of OPN, the evidence for its functional role in tumor cell metastasis, the downstream signals that activate invasive mechanisms, and the recent reports concerning regulation of OPN transcription. 15501463 2004
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 Biomarker phenotype BEFREE Several potential targets in the pathway can be manipulated to block the synthesis of osteopontin and inhibit liver cancer metastasis. 14716823 2004
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 AlteredExpression phenotype BEFREE Thus, we investigated the transcriptional activation of the OPN promoter in the human metastatic cancer cell line A2058. 14712233 2004
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 Biomarker phenotype BEFREE Understanding the molecular mechanisms that underlie regulation of transcription of the human osteopontin encoding gene (OPN) may help to clarify several processes, such as fibrotic evolution of organ damage, tumorigenesis and metastasis, and immune response, in which OPN overexpression is observed. 15479859 2004
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 AlteredExpression phenotype BEFREE These results suggest that the presence of these transcription factors in human breast cancer is responsible in part for the overexpression of OPN that, in turn, is implicated in mammary neoplastic progression and metastasis. 14990565 2004
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 AlteredExpression phenotype BEFREE Downregulation of osteopontin and bone sialoprotein II is related to reduced colony formation and metastasis formation of MDA-MB-231 human breast cancer cells. 14647232 2004
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 Biomarker phenotype BEFREE In particular, in collaboration with the National Institute of Health (NIH) in the United States, we generated a molecular signature that can classify metastatic HCC patients, identified osteopontin as a lead gene in the signature, and found that genes favoring metastasis progression were initiated in the primary tumors. 14685850 2004
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 GeneticVariation phenotype BEFREE Molecular factors involved in the process of HCC invasion and metastasis, including adhesion molecules (E-cadherin, catenins, ICAM-1, laminin-5, CD44 variants, osteopontin), proteinases responsible for the degradation of extracellular matrix (MMPs, uPA system), as well as angiogenesis regulators (such as VEGF, intratumor MVD), have also been shown to be potential predictors for HCC metastatic recurrence and clinical outcomes. 15205947 2004
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 Biomarker phenotype BEFREE Osteopontin (OPN) is an integrin-binding protein that has been shown to be associated with the progression of several cancer types, and to play an important functional role in various aspects of malignancy, particularly tissue invasion and metastasis. 15864800 2005
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 Biomarker phenotype BEFREE The extracellular matrix (ECM) molecule osteopontin is implicated in many pathologic processes, including inflammation, cell proliferation, ECM invasion, tumor progression, and metastasis. 16000556 2005
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 Biomarker phenotype BEFREE OPN is the major phosphoprotein secreted by malignant cells in patients with advanced metastatic cancer, is frequently overexpressed in human tumors, and has been implicated as a key mediator of tumor cell metastasis. 16047475 2005
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 Biomarker phenotype BEFREE Our results do suggest, however, that blockade of OPN might be useful as a therapeutic approach to inhibit invasion and metastasis of pancreatic cancer cells. 15970685 2005
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.400 Biomarker phenotype BEFREE In addition to those described above, genes such as OPN, which is mainly involved in metastasis and recently reported to be down regulated by selenium, should be considered as potential molecular marker in clinical chemoprevention trials. 16099479 2005