Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker phenotype LHGDN Surgical excision promotes tumor growth and metastasis by promoting expression of MMP-9 and VEGF in a breast cancer model. 18438343 2008
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.600 AlteredExpression phenotype BEFREE In addition, RCC2 was able to activate JNK, while inhibition of JNK suppressed the effect of RCC2 on LUAD cell migration, invasion, EMT, and the expression of MMP-2 and MMP-9.<b>Conclusions:</b> RCC2 plays a pivotal role in LUAD metastasis by inducing EMT via activation of MAPK-JNK signaling.<i></i>. 28606921 2017
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.600 Biomarker phenotype BEFREE Intriguingly, HER2 inhibitors significantly reversed CUL4B-induced EMT in vitro and partially blocked GC metastasis in tumor xenografts with CUL4B overexpression. 29106389 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker phenotype BEFREE Knockdown of miR-574-5p induced an up-regulation of E-cadherin and down-regulation of cyclinD1, N-cadherin, matrix metallopeptidase 9 (MMP-9), and β-catenin in cervical cancer cells Moreover, QKI was verified as a target of miR-574-5p and involved in regulation of miR-574-5p-induced cervical cancer cell progression and metastasis. miR-574-5p functions to be oncogenic in cervical cancer, and its inhibition suppresses cervical cancer progression and metastasis as well as enhances chemosensitivity by targeting QKI. 31786621 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker phenotype BEFREE Down-regulation of Notch1 could be an effective approach for inhibition of the expression of matrix metalloproteinase (MMP)-2 and MMP-9 resulting in the inhibition of invasion and metastasis, which could be useful for devising novel preventive and therapeutic strategies for lingual squamous cell carcinoma. 21993452 2012
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.600 AlteredExpression phenotype BEFREE Tissue microarrays have been used to determine the frequencies of amplication of 3 major breast cancer genes and identify overexpression of ERBB2 mRNA; assess and compare gene amplification in benign prostatic hyperplasia, primary prostate carcinoma, recurrent prostate tumors, and metastatic tumors; compare aggressiveness of prostate carcinoma in 2 patient populations; and study gene amplification across various tumor types. 11504281 2001
Entrez Id: 301
Gene Symbol: ANXA1
ANXA1
0.600 Biomarker phenotype CTD_human AnxA1 promotes metastasis formation by enhancing TGFbeta/Smad signaling and actin reorganization, which facilitates an EMT-like switch, thereby allowing efficient cell migration and invasion of metastatic breast cancer cells. 20308542 2010
Entrez Id: 301
Gene Symbol: ANXA1
ANXA1
0.600 Biomarker phenotype BEFREE Finally, we show that ANXA1 overexpression enhances metastasis and reduces survival in an intracardiac metastasis model, while ANXA1-deficient mice crossed with MMTV-PyMT mice display significantly less metastasis than their heterozygous littermates, indicating that ANXA1 is an important gene in breast cancer metastasis. 21383699 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker phenotype BEFREE The variables associated with a shorter time to metastases/recurrence were gastrointestinal histology (P = 0.004), APC (P = 0.008), PTEN (P = 0.026) and TP53 (P = 0.044) alterations. 25928476 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 AlteredExpression phenotype LHGDN In conclusion, our results indicate that expression of c-erbB-2 and p53 did not have any prognostic value in patients with early-stage breast cancer in which axillary lymph node metastasis is absent. 17478762 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression phenotype LHGDN Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases. 15870920 2005
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.600 Biomarker phenotype BEFREE Ado-trastuzumab emtansine (T-DM1/Kadcyla<sup>®</sup>;Genentech) is an antibody-drug conjugate used in the treatment of human epidermal growth factor receptor-2-positive metastasized breast cancer. 30820718 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker phenotype BEFREE In addition, p53 modifies the ability of tumor cells to metastasize. 12669312 2003
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.600 Biomarker phenotype BEFREE Genetic alterations of the proto-oncogene human epidermal growth factor receptor (HER-2/neu) have been shown to induce malignant transformation and metastasis. 18837888 2008
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression phenotype BEFREE In addition, RCC2 was able to activate JNK, while inhibition of JNK suppressed the effect of RCC2 on LUAD cell migration, invasion, EMT, and the expression of MMP-2 and MMP-9.<b>Conclusions:</b> RCC2 plays a pivotal role in LUAD metastasis by inducing EMT via activation of MAPK-JNK signaling.<i></i>. 28606921 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker phenotype LHGDN Our observations indicate that the inhibition of cyclooxygenase-2 can lead to the regression of disseminated skin melanoma metastases, even after failure of chemotherapy. 16718274 2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression phenotype BEFREE The molecular mechanism underlying activation of matrix metallopeptidase 9 (MMP9) in non-small cell lung cancer (NSCLC) cells, which controls cancer invasiveness and metastasis, remains elusive. 24705809 2014
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker phenotype BEFREE Finally, silencing of COX-2 resulted in the inhibition of metastasis to the lungs of severe combined immunodeficient mice after intravenous injection. 17510310 2007
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.600 Biomarker phenotype BEFREE Here, we investigated whether rVP1 exhibits any inhibitory effects on migration/metastasis and human epidermal growth factor receptor 2 (HER-2), a well-known biomarker for poor prognosis of breast cancer. 22983836 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker phenotype BEFREE Thus, miR-129, EGFR, and MMP9 appear to be promising therapeutic targets for preventing the metastasis of NSCLC. 25716201 2015
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.600 Biomarker phenotype BEFREE ShcA is an important mediator of ErbB2- and transforming growth factor β (TGF-β)-induced breast cancer cell migration, invasion, and metastasis. 26976638 2016
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker phenotype BEFREE Identification of cyclooxygenase-2 as a major actor of the transcriptomic adaptation of endothelial and tumor cells to cyclic hypoxia: effect on angiogenesis and metastases. 20068092 2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression phenotype BEFREE Knockdown of TM4SF1 inhibited the migration and invasion of pancreatic cancer cells by regulating the expression and activity of MMP-2 and MMP-9, which suggests that TM4SF1 may play a significant role in metastasis in pancreatic cancer. 27459514 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker phenotype BEFREE These insights into the secretion of MMP-9 constitute the basis for the development of potential drugs against metastasis. 22406264 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker phenotype BEFREE Likewise, in the periphery, physiological events, as the involvement of MMP-9 in angiogenesis, for instance in wound healing, can be turned into pathological, such as in tumor metastasis, depending on the state of the organism. 29865065 2018