Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
0.100 Biomarker phenotype BEFREE In patients with ZES, increased PP levels were not related to the presence of MEAI or metastases; nor was there a correlation between serum PP and gastrin concentrations. 35434 1978
Entrez Id: 2520
Gene Symbol: GAST
GAST
0.090 Biomarker phenotype BEFREE In patients with ZES, increased PP levels were not related to the presence of MEAI or metastases; nor was there a correlation between serum PP and gastrin concentrations. 35434 1978
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 Biomarker phenotype BEFREE The best chance of cure lies in early diagnosis through the use of immunoreactive calcitonin measurement in family members at risk, and an aggressive surgical attack on the primary tumor and any cervical metastases. 1111937 1975
Entrez Id: 6401
Gene Symbol: SELE
SELE
0.100 Biomarker phenotype BEFREE These data suggest that this methodology is appropriate for dissecting the individual activities of E-selectin while minimizing the participation of other adhesion molecules, thereby allowing us to develop a better understanding of the role of E-Selectin and endothelia in metastatic disease. 1280420 1992
Entrez Id: 5670
Gene Symbol: PSG2
PSG2
0.100 AlteredExpression phenotype BEFREE CEA mRNA did not appear to correlate with metastasis because its expression in the primary colon cancers with metastases (Dukes' stage D tumor) was not always increased. 1290028 1992
Entrez Id: 1084
Gene Symbol: CEACAM3
CEACAM3
0.100 AlteredExpression phenotype BEFREE CEA mRNA did not appear to correlate with metastasis because its expression in the primary colon cancers with metastases (Dukes' stage D tumor) was not always increased. 1290028 1992
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 AlteredExpression phenotype BEFREE CEA mRNA did not appear to correlate with metastasis because its expression in the primary colon cancers with metastases (Dukes' stage D tumor) was not always increased. 1290028 1992
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 AlteredExpression phenotype BEFREE CEA mRNA did not appear to correlate with metastasis because its expression in the primary colon cancers with metastases (Dukes' stage D tumor) was not always increased. 1290028 1992
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 AlteredExpression phenotype BEFREE All four patients with tumor cells located in close proximity to the ductal basement membrane and over-expressing c-myc protein had positive lymph nodes, suggesting that these tumors are more likely to metastasize. 1309531 1992
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 AlteredExpression phenotype BEFREE 10-fold) only in metastases induced by one out of 3 metastatic hybrids tested; (2) to the transcription level of c-Ha-ras and c-Ki-ras genes which was enhanced (approx. 1309725 1992
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.100 AlteredExpression phenotype BEFREE 10-fold) only in metastases induced by one out of 3 metastatic hybrids tested; (2) to the transcription level of c-Ha-ras and c-Ki-ras genes which was enhanced (approx. 1309725 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker phenotype BEFREE There were statistically significant associations, independent of other prognostic factors, between p53 protein accumulation and metastasis-free and overall survival, for randomly accrued and for both sporadic and familial tumors. 1317462 1992
Entrez Id: 8190
Gene Symbol: MIA
MIA
0.100 Biomarker phenotype BEFREE We evaluated the possibility that expression of this antigen, which can be defined by the monoclonal antibody MIA-15-5, might be of prognostic value, as suggested by our previous observation that MIA-15-5 inhibits tumor-cell motility and metastasis. 1317941 1992
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Interestingly, the primary tumor C15 showed a profile of TNF-sensitive tumor while C17, C18 and C19 which were derived from metastasis have a typical profile of TNF-resistant cells. 1325786 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation phenotype BEFREE The association of p53 mutation with metastases may explain the poor prognosis reported for HPV negative primary cancers, many of which already contain mutant p53. 1327751 1992
Entrez Id: 6275
Gene Symbol: S100A4
S100A4
0.400 AlteredExpression phenotype BEFREE The mts1 gene is specifically expressed in certain metastatic tumors but not in their nonmetastatic counterparts. 1329089 1992
Entrez Id: 6298
Gene Symbol: SAI1
SAI1
0.100 AlteredExpression phenotype BEFREE The mts1 gene is specifically expressed in certain metastatic tumors but not in their nonmetastatic counterparts. 1329089 1992
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 AlteredExpression phenotype BEFREE The mts1 gene is specifically expressed in certain metastatic tumors but not in their nonmetastatic counterparts. 1329089 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation phenotype BEFREE All 6 patients had primary and metastatic tumor expressing a mutant p53. 1331352 1992
Entrez Id: 4610
Gene Symbol: MYCL
MYCL
0.100 Biomarker phenotype BEFREE Our results indicate that, in patients with lung cancer, genetic disposition with respect to the L-myc gene influences the extent of metastasis, the incidence of multiple cancers and prognosis. 1347036 1992
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.100 AlteredExpression phenotype BEFREE Because expression of ICAM-1 in melanoma was found to correlate with increased risk of metastasis, the regulation of ICAM-1 expression on human melanocytes and melanoma cells was investigated. 1347555 1992
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.600 Biomarker phenotype BEFREE Overall, 16 out of 17 (94%) tumors of the patients having amplified HER-2/neu had metastatic disease at the time of diagnosis. 1349794 1992
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.600 AlteredExpression phenotype BEFREE HER-2 expression was also associated with a poorer survival among patients who had axillary nodal metastases (P = .003; n = 104), but not among those patients who did not have metastases. 1351537 1992
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.600 AlteredExpression phenotype BEFREE c-erbB-2 expression in primary gastric carcinomas and their metastases. 1353880 1992
Entrez Id: 5340
Gene Symbol: PLG
PLG
0.100 Biomarker phenotype BEFREE Since tetranectin binds to plasminogen we hypothesize that it could function as an anchor and/or reservoir for plasminogen and similar substances that regulate tumor invasion and metastasis as well as tumor angiogenesis. 1354271 1992