Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Metastasis suppressor NM23 limits oxidative stress in mammals by preventing activation of stress-activated protein kinases/JNKs through its nucleoside diphosphate kinase activity. 28077425 2017
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Metastasis Suppressor NME1 Directly Activates Transcription of the <i>ALDOC</i> Gene in Melanoma Cells. 30396920 2018
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Nm23-H1 and nm23-H2 are putative metastasis suppressor genes that encode nucleoside diphosphate kinase (NDPK) A and B. NDPKs form oligomers distributed between soluble and particulate fractions of cells and therefore may exert their effects as either soluble or bound proteins. 11058869 2000
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway. 12105213 2002
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE Nm23 expression was significantly reduced and Ki67 antigen expression increased in primary tumours with either lymph node or organ metastases in comparison to tumours without metastases. 16277028 2005
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Nm23-H1 encodes nucleoside diphosphate kinase A and acts as a suppressor of metastasis in certain human tumors. 16814409 2006
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE NM23, the first metastasis suppressor gene to be identified, has been widely studied in human cancers. 16944304 2006
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Nm23-H1: a metastasis-associated gene. 17197349 2006
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE NM23 is one of the human metastasis suppressor genes. 17885583 2007
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE NM23-H1 is a multifunctional protein, which, in addition to limiting metastasis, has DNase and histidine protein kinase activities. 17975005 2007
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Nm23-H1 was discovered as the first metastasis suppressor gene about 20 years ago. 19412732 2009
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Nm23-H1 is a well-known tumor metastasis suppressor, which functions as a nucleoside-diphosphate kinase converting nucleoside diphosphates to nucleoside triphosphates with an expense of ATP. 20448457 2010
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE nm23, a tumor metastasis suppressor gene, has been linked to protection against tumorigenesis and tumor metastasis. 22683585 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE NME1 is a wide-spectrum tumor metastasis suppressor gene that plays an important role in suppressing the invasion and metastasis of tumor cells. 23856325 2013
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Nm23-H1 is a metastasis suppressor gene whose overexpression is associated with both reduced cell motility in various cancers and increased metastatic potential in neuroblastomas, osteosarcomas, and hematological malignances. 25138575 2015
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Nm23 is a metastasis suppressor gene whose downregulation triggers metastatic progression. 25321081 2015
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE NM23-H1 is the first metastasis suppressor gene identified and known to be implicated as an important regulator of stress-induced metastasis. 28216015 2017
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE NM23 is a multifunctional gene, which inhibits tumor metastasis and regulates cell proliferation, differentiation, development, and apoptosis; however, there is little research about NM23 in promoting liver cell proliferation. 29078900 2017
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE NM23/NDPK proteins have been studied for their metastasis suppressor role but the molecular pathways involved in this process are not very vivid. 29083410 2018
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE Nucleoside diphosphate kinase A (NDPKA) expression before and after transfection was examined, as well as changes in cell invasiveness and metastasis capabilities. 29272002 2017
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE nm23 has properties of a metastasis suppressor gene and also has been implicated in the control of response to transforming growth factor beta 1 (TGF beta 1) by studies in melanoma cells. 7819128 1994
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Nm23 is a putative metastasis suppressor gene and alterations in this gene have been reported in colorectal carcinomas suggestive of a role for nm23 in the dissemination of these tumours. 8195929 1994
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Nm23 is a gene associated with low tumor metastatic potential and has been proposed to be a metastasis suppressor gene. 8199988 1994
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE nm23 has been recognized as a potential suppressor gene of metastasis. 9570214 1998
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE A detailed study of the structure and function of the promoter element of the nm23-H1 gene will help in understanding the regulatory mechanisms of nm23 expression and its role in tumor progression, especially in metastasis. 8084595 1994