Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE High level of Nm23-H1 gene expression is associated with local colorectal cancer progression not with metastases. 7947079 1994
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE We also described the current understanding of the cellular and viral interactions of Nm23-H1 and their reference to transcription regulation and metastasis. 29035376 2018
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein. 27449069 2016
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE These results suggest that nm23 overexpression is linked with development of gastric carcinomas and the decrease in expression of nm23 participates in metastasis. 8096503 1993
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE However, mRNA levels of both nm23 genes were not associated with histological grade, pathological stage, tumor metastasis or prognosis. 7614395 1994
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE These findings suggest that impairment of nm23-H1 expression is an early event into the progression of colorectal metastasis that precedes E-cadherin transcriptional silencing in the majority of SCRCs examined. 12684753 2003
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE This study examined the effect of n-6 polyunsaturated fatty acids (PUFAs) on the expression of nm-23, a metastasis-suppressor gene, in two highly invasive human cancer cell lines, HT115 and MDA MB 231. 9514051 1998
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Expression of metastasis associated proteins, CD44v6 and NM23-H1, in pediatric acute lymphoblastic leukemia. 11299850 2001
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE One gene postulated to play a role in tumour metastasis suppression is NME1 (nm23-H1), and an inverse relationship between NME1 expression and metastatic potential has been observed for some solid tumours. 7622307 1995
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE The results suggest that the metastasis suppressing function of nm23-H1 is independent of the NDPK enzymatic activity. 10530775 1999
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE However, this trend was not maintained in cancer cells from tumors that metastasized to axillary lymph nodes and in metastatic cells; in these 2 situations the NM23.H1 mRNA content varied without any relationship to the proliferative rate of the cells. 9036878 1997
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE There was no significant association between nm23-H1 expression, histologic type and age of the patients. nm23-H1 expression was not seen in our cases with metastasis and this may be related to nm23 gene alterations not being detectable by the monoclonal antibody used or to the presence of a subset of tumors in which nm23 gene abnormalities had not yet occurred at the time of tumor excision or biopsy. 10523705 1999
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Nm23 is a putative metastasis suppressor gene and alterations in this gene have been reported in colorectal carcinomas suggestive of a role for nm23 in the dissemination of these tumours. 8195929 1994
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE nm23, a tumor metastasis suppressor gene, has been linked to protection against tumorigenesis and tumor metastasis. 22683585 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 PosttranslationalModification phenotype BEFREE The time from biopsy of the primary MM to the appearance of the first lymph node metastasis also showed a positive correlation with the nm23 mRNA level in this metastasis. 7981081 1994
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE We have employed a site-directed mutagenesis approach to demonstrate that the 3'-5' exonuclease activity of NM23-H1 is required for its metastasis suppressor function. 19381784 2009
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Given the fact that not all NME-encoded proteins are catalytically active NDPKs and that NM23 generally refers to clinical studies on metastasis, we use here NME/NDPK to denote the proteins. 29451272 2018
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE It is highly homologous to the putative metastasis suppressor nm23-H1 gene and the closely related nm23-H2 gene. 9067290 1997
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE The product of Nm23 gene has been proposed as a candidate tumour metastasis suppressor protein. 8394105 1993
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE The h-prune-nm23-H1 protein complex and its activation of PDE-cAMP activity have been shown to correlate with breast cancer progression and metastasis formation. 17103319 2006
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 GeneticVariation phenotype BEFREE Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1. 8270257 1994
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE nm23 has properties of a metastasis suppressor gene and also has been implicated in the control of response to transforming growth factor beta 1 (TGF beta 1) by studies in melanoma cells. 7819128 1994
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Pilot in vivo metastasis assays indicate 1205Lu cells are highly responsive to the metastasis suppressor effects of NM23-H1, thus providing a valuable model for measuring the extent to which the nuclease function opposes metastasis and metastatic progression. 17039395 2006
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE A human gene, nm23-H1, has been known as a metastasis suppressor in many tumor cells. 10072163 1998
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 GeneticVariation phenotype BEFREE The metastasis-associated gene Nm23-H1, which encodes an 18-kDa nucleoside diphosphate kinase, was previously identified in cells with low metastatic potential. 12669312 2003