Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE A never-smoking status was related to better survival outcome, whereas EGFR mutation, two or more metastatic sites, and intra-abdominal metastasis were each associated with a poor PFS. 27388008 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Activation of the ERBB PI3K/Akt pathway was positively correlated with a higher stage (p=0.001), higher grade (p=0.001), histological type II disease (p=0.0003) and metastases (p=0.02). 24337234 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Lung adenocarcinoma with EGFR gene mutations had longer DFI than those with wild-type EGFR gene, especially with regard to distant metastasis. 29878144 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE We report two cases of lung adenocarcinoma with EGFR exon 20 mutations and a presentation of diffuse, tiny, innumerable lung and brain nodules resembling miliary metastases. 30648067 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Five of them were given gefitinib as neoadjunvant treatment after the EGFR-TKI sensitive mutations were detected in their biopsies of mediastinal lymph nodes metastases. 21414214 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE ErbB-2 amplification with a gene copy number > 1.6 in tumour tissue and erbB-1 deletion with a gene copy number < 0.4 in tumour-surrounding mucosa are of clinical relevance and indicate an early tumour recurrence or metastasis (p < 0.05). 10889928 2000
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE EGFR mutation ratios in primary tumors and metastatic tumors are different. 24398248 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Additionally, EGFR mutation (P = 0.005), good performance status (P < 0.001) and absence of extracranial metastases (P=0.033) correlated with better survival. 23871711 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Brain metastases from breast and other primary sites, and metastases to multiple organs in the autopsied cases, also contained somatic mutations in EGFR, HRAS, KRAS, NRAS or PIK3CA. 20604919 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Functional outcomes and survival after surgical stabilization for inoperable non-small-cell lung cancer with spinal metastasis of the thoracic and lumbar spines: a retrospective comparison between epidermal growth factor receptor-tyrosine kinase inhibitor and platinum-based chemotherapy groups. 31501501 2020
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Six independent prognostic factors including sex (P = 0.008), the presence of visceral metastasis (P = 0.008), the number of metastases in the vertebral body (P = 0.011), Frankel score (P < 0.001), D-dimer (P = 0.002), and sensitive epidermal growth factor receptor mutation (p < 0.001) were identified and entered into the nomogram. 30059487 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Next to investigate the relationship between EGFR mutations and tumor metastasis, we compared the DNA sequences of the EGFR gene between the primary tumor and the lymph node metastasis in 31 clinical samples. 21953075 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE A combined test using both cell sediment DNA and supernatant ccfDNA samples increases the concordance rate of EGFR mutations between primary tumour and corresponding metastases. 29363841 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE However, features of metastasis to other organs and the independent prognostic influence of metastatic lesions were not elucidated in patients with lung cancer harboring EGFR mutations. 24682604 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Phase II/III data however, from non-EGFR mutation enriched populations, have demonstrated no benefit in progression free or overall survival with the addition of erlotinib to metastasis directed radiotherapy. 26967582 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Conclusions Incorporation of EGFR mutation status in advanced NSCLC further differentiates survival curves of M categories in 8th TNM classification and more precisely predicts survival compared to number of metastasis or number of metastatic sites alone. 31747381 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE The impact of EGFR signaling on tumor cell migration was studied in vitro by using 11 primary human adaCP cultures treated with the EGFR ligand EGF and its inhibitor gefitinib. 21562037 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE The rates of bone (32.2 vs 22.8 %, P = 0.007) and brain (16.3 vs 9.4 %, P = 0.008) metastasis were significantly higher in EGFR mutation group than the wild-type group. 26589606 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE The incidence of EGFR gene mutations in the bone metastases was 75%, in the primary adenocarcinoma--12.8%, and in the adenocarcinoma metastases to CNS--14.75%. 23852459 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Factors such as tumor pathology subtype, concurrent systemic chemotherapy, epidermal growth factor receptor (EGFR) mutation status, use of EGFR tyrosine kinase inhibitors (TKIs), systemic disease status, presence of a metastatic lesion only in delayed MRI, and volume and number of metastases were analyzed. 28074321 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE The discovery of anti-EGFR resistance in the setting of Kirsten rat sarcoma viral oncogene (KRAS) and more recently, neuroblastoma RAS viral oncogene (NRAS) mutations in CRC has changed the focus of therapy for metastatic disease to one based on the molecular characteristics of the tumor. 25374966 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Patients had advanced NSCLC, oncogenic EGFR mutations in the tumor, and no prior chemotherapy for metastatic disease and were treated with erlotinib or chemotherapy. 26181014 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE The frequency of distant metastasis was significantly higher in the mutant EGFR group compared with the wild-type EGFR group. 28693247 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Finally, TrkB expression was correlated with metastasis in patient samples, and TrkB was detected more often in tumors that did not have Kras or epidermal growth factor receptor mutations. 24982195 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE No significant differences were observed in the occurrence of EGFR gene mutations in primary tumors compared to metastases (7.9% vs. 11.2%; p=0.092), or in FFPE samples compared to cytological samples (8.9% vs. 8.1%; p=0.813). 25534657 2015