Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE A never-smoking status was related to better survival outcome, whereas EGFR mutation, two or more metastatic sites, and intra-abdominal metastasis were each associated with a poor PFS. 27388008 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE Moreover, the alteration of MMP-2, MMP-9, TGF-β and epidermal growth factor receptor (EGFR) expression, associated with the migration and metastasis potential of lung cancer cell lines, was identified by western blot analysis in transfected cells. 26151179 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE We analyzed the concordances of downstream EGFR effectors in tumoral pairs of primaries and related metastases in a series of KRAS wild-type patients. 22229245 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Our results indicate that the heterogeneity in primary colon carcinoma and its corresponding lymphatic and hepatic metastases may result in differences in the response to dual-inhibition of EGFR and VEGF. 22581265 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Activation of the ERBB PI3K/Akt pathway was positively correlated with a higher stage (p=0.001), higher grade (p=0.001), histological type II disease (p=0.0003) and metastases (p=0.02). 24337234 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE In conclusion, EGFR and HER3 expression in metastasized NSCLC patients have considerable value for CTC isolation plus multiple markers can provide a novel liquid biopsy approach. 31092882 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Mechanistic studies revealed that PEAK1 is induced by epidermal growth factor receptor (EGFR) signaling and that PEAK1 is required for KRas-induced CRC cell growth and metastasis. 29449544 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE The incidence of brain (39.2% vs. 28.2%, <i>p</i> = 0.038) and lung (61.2% vs. 51.0%, <i>p</i> = 0.048) metastasis was higher in the <i>EGFR+</i> cohort than in the <i>EGFR</i> wt cohort. 28874890 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE Moreover, the expression levels of EMT‑ and metastasis‑associated genes were found to be modulated by afatinib through EGFR inhibition. 31432165 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE The results indicate that CUL1 knockdown prohibited the metastasis behaviors of breast cancer cells through downregulation (dephosphorylation) of the EMT signaling pathways of EGFR and Akt/GSK3β/β-catenin in breast cancer. 31175550 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE The receptor tyrosine kinase EGFR may be involved in late stage melanoma; the human exon with homology to Xmrk shows elevated transcription levels in 80% of human melanoma metastases. 7882274 1995
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Ultrasonography-Guided Core Biopsy of Supraclavicular Lymph Nodes for Diagnosis of Metastasis and Identification of Epidermal Growth Factor Receptor (EGFR) Mutation in Advanced Lung Cancer. 26200642 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE The monoclonal antibody cetuximab, which displays EGFR extracellular domain-specific binding, has proven effective in the treatment of locally advanced disease and relapsed/metastatic disease. 31615015 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Lung adenocarcinoma with EGFR gene mutations had longer DFI than those with wild-type EGFR gene, especially with regard to distant metastasis. 29878144 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE The epidermal growth factor receptor (EGFR) pathway is important in tumor growth, survival, and metastasis and is now the target of several therapeutic agents. 24054705 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE The above data demonstrate that EGFR-overexpressing invasive cells have the ability to compensate the loss of MAPK-mediated signaling through activation of PKC-delta signaling for cell migration, which plays a major role in invasion and metastasis. 14517342 2003
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Regulation of epidermal growth factor receptor signaling by plasmid-based microRNA-7 inhibits human malignant gliomas growth and metastasis in vivo. 23373996 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE In certain human cancers, PI3K works synergistically with EGFR to promote proliferation, survival, invasion and metastasis. 29407971 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE We report two cases of lung adenocarcinoma with EGFR exon 20 mutations and a presentation of diffuse, tiny, innumerable lung and brain nodules resembling miliary metastases. 30648067 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE EGFR expression was more frequent in metastases (41%) than in primary tumours (16%). 17541441 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Five of them were given gefitinib as neoadjunvant treatment after the EGFR-TKI sensitive mutations were detected in their biopsies of mediastinal lymph nodes metastases. 21414214 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Concomitant overexpression of the EGFR and erbB-2 genes in renal cell carcinoma (RCC) is correlated with dedifferentiation and metastasis. 8600053 1996
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Because metastasis requires the coordinate expression of multiple genes, down-regulation of at least one important gene, such as the epidermal growth factor receptor, had the ability to suppress metastasis. 18211900 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE In turn, TGFα stimulated EGFR, which potentiated SMAD signaling, reinforcing EMT and metastasis. 29339541 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE There was a good concordance between the primary tumors and the paired metastases regarding EGFR expression. 18700025 2008