Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE "Caged" reagents for miRNA research (siRNA targeting EGFR, involved in miRNA maturation, and mimics of miR-20a, playing a key role in tumor formation and metastasis) were prepared. 27484612 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Metastases in breast cancer are a vital concern in treatment, with epidermal growth factor receptor and ErbB2 strongly implicated in mediating tumor invasion and spreading. 15690056 2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Metastasis of non-small cell lung cancer (NSCLC), indicating hematogenous dissemination, is more frequent in patients harboring epidermal growth factor receptor (EGFR) mutations, who respond dramatically to EGFR-tyrosine kinase inhibitors (TKIs). 29858682 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE EGFR amplification, observed as scattered signals reminiscent of amplicons in double minute chromosomes, or coamplification of EGFR with the centromeric regions was observed as a minor population within primary tumors, and found in variety of populations in metastatic tumors. 15143334 2004
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE EGFR was overexpressed in this CRC patient population and was significantly associated with TNM (tumor-node-metastasis) stage T3. 15598946 2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE EGFR had a similar and high expression in both primary tumours and the corresponding metastases, while the expression in normal epithelium was lower in most cases. 15809707 2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE Epidermal growth factor receptor (EGFR) mediated mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway was isolated as invasion-metastasis related factor in pancreatic cancer in our previous studies. 15809719 2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Epidermal growth factor receptor-mediated signaling promotes tumorigenesis and metastasis of cancer cells. 15867774 2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE Epidermal growth factor receptor and ephrin B2 mRNA expression was elevated in higher TNM stage neoplasms and in patients with high-risk AMES (Age, distant Metastasis, Extrathyroidal invasion, and tumor Size) differentiated thyroid cancers (P < or = .005). 16360397 2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE EGFR and p-EGFR expression did not correlate with the clinical factors tumor stage, regional lymph node metastasis, or distant metastasis. 16799709 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE EGFR expression was more frequent in metastases (41%) than in primary tumours (16%). 17541441 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE EGFR expression was positively correlated with nuclear grade (P = 0.001) and negatively correlated with the hormonal receptor oestrogen receptor (P = 0.005). pEGFR was positively related to the Akt pathway (P = 0.008) and appeared to participate in invasion and metastasis (uPAR, P = 0.049; MMP-14, P = 0.025; VEGFR-1/Flt-1, P = 0.016). 18522728 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE EGFR activation results in a series of downstream signaling events that mediate cancer cell growth, proliferation, motility, adhesion, invasion, apoptosis inhibition and metastasis as well as resistance to chemotherapy. 18712184 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE EGFR mutations in primary lung tumors do not always reflect the same situation in metastases. 19088172 2009
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE EGFR protein overexpression was significantly higher in metastasis sites than in primary tumors. 19138956 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE EGFR FISH was positive in 28% of the primary tumors and in 45% of the metastases (p < 0.05). 19404216 2009
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE EGFR expression levels in the primaries and in the metastases do not appear to be useful prognostic markers. 20595818 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE EGFR and HER2 positivity are more frequently found in favorable histological risk group of tumours (P = 0.004 and P = 0.01 respectively) while high expression of HER4 is significantly more often found in patients with metastatic disease (P = 0.03). 21203803 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE EGFR appears to be involved in progression and metastasis of a subset of melanomas. 21352258 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE EGFR mutations showed a discordance rate of 16.2% (6 of 37 patients) between primary lung adenocarcinomas and corresponding metastases. 21729655 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Epidermal growth factor receptor (EGFR) plays an important role in the growth and metastasis of many solid tumors. 22392077 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE EGFR mutations were found in 14 of 49 cases (29%), including 5 primary and 9 metastatic tumors. 23495083 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE Epidermal growth factor receptor (EGFR) transmembrane glycoprotein has been demonstrated to be overexpressed in pancreatic cancer, and it correlates with more advanced disease, poor survival, and the presence of metastases. 23560505 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression phenotype BEFREE EGFR expression was observed in 73.3% of tumors (44/60); positive EGFR expression was significantly correlated with tumor-node-metastasis (TNM) staging, lymph node metastasis, and distant metastasis (P < 0.05). c-Fos expression was found in 85% (51/60) of tumors, and its expression was significantly related to tumor depth and TNM staging (P < 0.05). c-erb-B2 expression was 75% (45/60) in esophageal squamous cell carcinoma (ESCC) specimens, and positive-erb-B2 expression had a significant association with the depth of tumor invasion (P < 0.05). c-Fos expression was significantly and positively correlated with c-erb-B2 (P < 0.05). 24052437 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE EGFR mutation ratios in primary tumors and metastatic tumors are different. 24398248 2014