Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Evidence for a metastasis suppressor function of NME1 in vivo comes from crossing NME1 (-/-) mice with mice prone to develop hepatocellular carcinoma; the double transgenic mice present a higher incidence of lung metastases. 21562815 2011
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE It is hypothesized that, NM23, as a metastasis suppressor gene, may be a good indicator of patients with breast cancer in most reports. 28161101 2017
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE Our findings suggest a correlation between high levels of NM23-H1 protein in the cytoplasm of the cells and progression of prostate cancer to metastasis, thus definitively identifying NM23-H1 as a new negative prognostic marker in prostate cancer. 21553004 2011
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Our limited study provides evidence for role for Nm23-H1 in HCV mediated cancer metastasis. 28376369 2017
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Upon mammary fat pad or subcutaneous injection into nude mice, both the nm23-H1 and control transfected lines produced primary tumors; however, the nm23-H1-transfected lines produced metastases in significantly fewer mice than did control transfected lines. 8395676 1993
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Our results are consistent with other studies reporting that NME1 down-regulation induces CIN in human cell lines and suggest that Drosophila model could be successfully used to study in vivo the impact of NME/Awd - induced genomic instability on tumour development and metastasis formation. 29203880 2017
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE Change in nm23-H1 expression and the PIK3/AKT pathway are involved in carcinogenesis, development, invasion and metastasis of ovarian cancers. 18949358 2008
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Six metastasis suppressor genes (nm23-H1, TIMP-4, BRMS-1, TXNIP, CRSP-3 and E-Cad) were downregulated significantly in malignant compared to benign pheochromocytoma (p < 0.05, Mann-Whitney U-test). 15523699 2005
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Conflicting results exist regarding the significance of the metastasis suppressor gene nm23-H1 in cancer patients. 17591363 2007
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Herein, we have unmasked a novel role for NME1 as a driver of melanoma growth distinct from its canonical function as a metastasis suppressor. 31123173 2019
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE We developed a competitive permeable peptide (CPP) to impair the formation of the Nm23-H1/h-Prune complex and demonstrated that CPP causes impairment of cell motility, substantial impairment of tumor growth and metastases formation. 23448979 2013
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE The h-prune PDE activity, suppressed by dipyridamole and enhanced by the interaction with nm23-H1, stimulates cellular motility and metastasis processes. 14998490 2004
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE Apart from a housekeeping function, NM23 proteins are involved in the regulation of many cellular processes as well as in tumor metastasis, but their functions in epidermal homeostasis and repair are largely unknown. 16862176 2007
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE There was no inverse correlation between the nm23 protein and melanoma metastasis which suggested that the nm23 protein does not appear to be lost during melanoma metastasis. 8971556 1996
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE The EBV critical latent antigens EBNA1 and EBNA3C interact with Nm23-H1, a known suppressor of cell migration and tumor metastasis. 17634231 2007
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE In sharp contrast, the low frequency of loss at NME1 and its equal distribution in nodal metastasis-positive and -negative patients suggests that inactivation of this gene by allelic loss probably does not play a role in the development of regional metastases from these tumors. 8174043 1994
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE The nm23 protein expression was significantly related to the tumor gross appearance, lymph node and peritoneal metastasis (P<0.05). 15040016 2004
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 GeneticVariation phenotype BEFREE Two-dimensional gel electrophoresis and liquid chromatography-tandem mass spectrometry were performed to investigate the influence of human nonmetastatic clone 23 type 1 (nm23-H1), a metastasis-associated gene on proteomic alterations in cancer cells of the uterine cervix. 26716410 2016
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE The significance of metastasis-related factors cathepsin-D and nm23 in advanced ovarian cancer. 10631462 1999
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE Interestingly, 17β-HSD1 increases the mRNA transcript (by 3.6 times) and the protein expression of the metastasis suppressor gene nm23-H1 and the expression of the two enzymes are closely correlated. 22691413 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE We hypothesize that a histidine protein kinase activity of Nm23 underlies its suppression of metastasis, and identify candidate substrates. 12848344 2003
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE We summarize published and recent research concerning the nm23 gene in breast cancer metastasis. 8347849 1993
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 AlteredExpression phenotype BEFREE Results show that The MDV and PCNA index in the group with intrahepatic metastasis is remarkably higher than that in without one (p<0.01), but the abundance of nm23-H mRNA is opposite (p<0.01). 9894772 1998
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE The human nucleoside diphosphate (NDP) kinase A, product of the NME1 gene also named NM23-H1, is known as a metastasis suppressor protein. 21484438 2011
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.400 Biomarker phenotype BEFREE These results demonstrated that nm23-H1 can suppress the mobility and metastatic capacity of cancer cells and the molecular mechanism by which nm23-H1 suppresses tumor metastasis may be via increasing the expression of metastasis-related genes such as beta-Catenin, E-Cadherin and TIMP-1 and decreasing the expression of MMP-2, CD44V6 and VEGF. 17167724 2006