Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Consistently, tRF3E levels significantly decrease in the blood of patients with epidermal growth factor receptor 2 (HER2)-positive BC reflecting tumor status (control > early cancer > metastatic cancer). tRF3E down-regulation was recapitulated in Δ16HER2 transgenic mice, representing a BC preclinical model. 31560576 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Cell-surface receptors (e.g., EGFR and integrin) and their interactions play determining roles in signal transduction and cytoskeletal activation, which affect cell attachment/detachment, invasion, motility, metastasis (intracellular), and cell-cell signaling. 31515999 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Among patients with EGFR mutation and distant metastasis, median PFS was decreased in those with co-mutations (6.3 months [95% CI 3.25-9.35] vs 22.0 months[95% CI 12.10-31.90]; HR 0.12 [95% CI 0.00-5.87]; p = 0.007) and frequency of PIK3CA (0% [0/12] vs 41.7% [5/12], p = 0.037) and PI3K/AKT/mTOR pathway genes (0% [0/12] vs 50% [6/12], p = 0.014) was lower. 31463717 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE The combination of fluorouracil and irinotecan with a BRAF<sup>V600E</sup> and EGFR inhibitor may have synergistic action, leading to recession of secondary metastases in patients with BRAF<sup>V600E</sup>-mutated colorectal cancer. 30662270 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE This case suggests that the mechanism by which miliary patterned metastases occur is more complex than purely mutation of the EGFR gene. 31151972 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Signal transducer and activator of transcription 3 (STAT3) and its mediated signal transduction pathway play an important role in the occurrence, development and metastasis of CRC, and are related to the development of EGFR-TKI resistance in CRC. 31308698 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE ALK-positive (ALK+) lung adenocarcinoma usually shows a more advanced-staged disease with frequent nodal metastasis and highly aggressive outcomes compared with EGFR-mutated lung cancers. 30580903 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE These data suggested that curcumin may control the EGFR and TLR4/MyD88 pathways to synergistically downregulate downstream cell cycle‑ and EMT‑related regulators, in order to block cell proliferation and metastasis in NSCLC. 31432177 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Analysis of mechanisms suggests that TNuF downregulates EGFR and VEGF signaling pathways, inhibiting angiogenesis and metastasis. 31426614 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE The objective of our study was to analyze the differences in survival between the different metastatic patterns of intrathoracic metastases in lung adenocarcinoma patients who have epidermal growth factor receptor (EGFR) mutations. 30854135 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE The G allele in rs7795743 in EGFR had an OR for metastasis of 0.68 (p-value = 0.02) and hazard ratio (HR) for progression of 0.66 (p-value = 0.004). 30827726 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Epidermal growth factor receptor family members such as ErbB1 and ErbB3 are involved in tumor progression and metastasis. 30621788 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Knockdown of EGFR abolished RHAMM<sup>B</sup>-driven PNET metastasis. 31072393 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE A Novel Mutant of rLj-RGD3 (rLj-112) Suppressed the Proliferation and Metastasis of B16 Cells through the EGFR Signaling Pathway. 30821275 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Mechanisms of the GE11-Evo-NPs against EGFR mediated invasion and metastasis of CRC were also explored. 31328737 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE The overall discordance rate in EGFR mutation between primary lung tumor and paired distant metastases in NSCLC is low, although higher discordance rates were observed in bone metastases compared with CNS and lung/pleural metastases. 31216329 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE In patients with NSCLC spinal metastasis, survival was associated with age, smoking, CA125, SCC, KPS, and EGFR status. 31028506 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE In advanced stages, patients with ALK-rearranged NSCLC, compared with EGFR-mutant NSCLC, were more likely to have lymphadenopathy (OR, 3.47; P < .001), pericardial metastasis (OR, 2.18; P = .04), pleural metastasis (OR, 2.07; P = .004), and lymphangitic carcinomatosis (OR, 3.41; P = .02), but less likely to have lung metastasis (OR, 0.52; P = .003). 31164317 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Moreover, combinatorial therapy with Bcl-2 and PKC-ι siRNAs loaded into the anti-EGFR QLs was remarkably effective in inhibiting tumor growth and metastasis. 30809312 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE We found an association between EGFR protein overexpression and intense EGFR immuno-staining in NPC samples with advanced tumor node metastasis stage, clinical stage and distant metastasis in NPC patients. 31665243 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation phenotype BEFREE Survival analysis underlined the good prognosis of EGFR-mutated adenocarcinoma in patients with intrapulmonary metastasis. 30721797 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Cetuximab can block the EGF-NF-κB-FOXK2-EGFR feedback loop and suppress CRC metastasis. 31281520 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Mechanistically, GPAA1 enhanced the levels of metastasis-associated GPI-anchored proteins to increase tumour metastasis and intensified lipid raft formation, which consequently promoted the interaction between EGFR and ERBB2 as well as downstream pro-proliferative signalling. 31118109 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Here we show that ectopic expression and therapeutic delivery of the secreted protein Tubulointerstitial nephritis antigen-like 1 (Tinagl1) suppresses TNBC progression and metastasis through direct binding to integrin α5β1, αvβ1, and epidermal growth factor receptor (EGFR), and subsequent simultaneous inhibition of focal adhesion kinase (FAK) and EGFR signaling pathways. 30612941 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker phenotype BEFREE Therefore, identification of promising therapeutic strategies targeting EGFR with higher specificity toward cancer metastasis is urgently needed. 30735802 2019