| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | AlteredExpression | phenotype | BEFREE | The results indicated that the knockdown of NSE led to downregulation of the pro-metastatic gene vascular endothelial growth factor (VEGF; P<0.05) and the upregulation of metastasis suppressor genes NM23 and E-cadherin (P<0.05). | 31611991 | 2019 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | CYFRA21-1 levels had stronger association with metastases and survival status than CEA and NSE in all lung cancer patients. | 28152979 | 2017 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | In addition, multivariate Cox regression analysis showed that NSE level > 50.324 ng/mL and distant metastasis were independently correlated with worse OS.Serum NSE and LDH could be promising biomarkers for predicting therapy response and survival of SCLC patients receiving first-line platinum-based chemotherapy. | 29145241 | 2017 | ||||
|
0.070 | AlteredExpression | phenotype | BEFREE | Neuron-specific enolase was highly expressed in both subcutaneous and metastatic tumors. | 26662423 | 2015 | ||||
|
0.070 | AlteredExpression | phenotype | BEFREE | The level of NSE correlates with tumour burden, number of metastatic sites and response to treatment.NSE can be also useful at diagnosis of NETs and gastroenteropancreatic (GEP)-NETs.Raised serum levels of NSE have been found in all stages of neuroblastoma, although the incidence of increased concentration is greater in widespread and metastatic disease. | 26530364 | 2015 | ||||
|
0.070 | AlteredExpression | phenotype | BEFREE | Furthermore, deguelin-treated tumors showed decreased the tumor metastasis related genes such as CD44, MMP2 and MMP9 at protein and mRNA levels and the content of CEA, SCC, NSE, CYFAR21-1. | 26884827 | 2015 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | A cell line producing carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) has been established from pleural effusion of the pulmonary metastatic tumor. | 2731119 | 1989 |