Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.070 | Biomarker | phenotype | BEFREE | These results suggest that PFKFB3 is essential for ROCK2-mediated proliferation and metastasis of osteosarcoma cells. | 31678169 | 2019 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | Furthermore, Pearson's correlation analysis revealed that PFKFB3 was signifcantly correlated with both CD163 and CD31 (P<0.05), meanwhile CD163 was signifcantly correlated with CD31 (P<0.001), suggesting PFKFB3 may promote angiogenesis in tumor progression and metastases by regulating CD163+ TAMs infiltration in OSCC. | 31209811 | 2019 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | PFKFB3 can be contributed to the progression and metastasis of cancer. | 29151977 | 2017 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | The pharmacological inhibition of PFKFB3 via PFK15 suppressed tumor growth and alleviated metastasis in HNSCC, offering a promising strategy for cancer therapy. | 28061878 | 2017 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | Notably, a regulator of the glycolytic pathway, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, controls vessel sprouting during the angiogenic switch and its inhibition in tumour ECs leads to vessel normalization, thereby reducing metastasis and ameliorating chemotherapy. | 29263247 | 2017 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | PFKFB3 blockade therefore results in tumor vessel normalization, with beneficial therapeutic effects on reduced metastasis and improved chemotherapy. | 28212191 | 2017 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | PFKFB3-blockade treatment also improved chemotherapy of primary and metastatic tumors. | 27866851 | 2016 |