Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE Accordingly, simultaneous inhibition of these RTKs using a multi-kinase inhibitor ponatinib has a superior effect at eliminating the CSC population and reduces metastasis of PIK3CA-overexpressing HNSCC cells. 31600013 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE Nectin-4 was overexpressed at all stages of metastasis and angiogenesis, thus appearing to play a major role in tumor relapse through the PI3K-Akt-NFκβ pathway. 31617074 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE Mutations activating the PI3K/AKT signaling pathway are observed in >40% of patients with CRC contributing to increased invasion and metastasis. 31704733 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression phenotype BEFREE VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR-PI3K-AKT pathway. 31605014 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE In this study, we aimed to investigate the effects of combined treatment with Notch1 signaling blocker DAPT and PI3K/Akt signal blocker LY294002 on metastasis of gastric cancer. 31732769 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression phenotype BEFREE Correction: VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR-PI3K-AKT pathway. 31700153 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE In summary, the Ras-PI3K passageway promoted cell growth and metastasis via decreasing H3K56ac, in which MDM2-mediated PCAF was involved. 31642074 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE Long non-coding RNA OECC promotes cell proliferation and metastasis through the PI3K/Akt/mTOR signaling pathway in human lung cancer. 31452780 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 GeneticVariation phenotype BEFREE KRAS, PIK3CA and TP53 mutations were associated with distant metastases and a poor prognosis. 30867754 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE SOCS5 inhibition induces autophagy to impair metastasis in hepatocellular carcinoma cells via the PI3K/Akt/mTOR pathway. 31406106 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression phenotype BEFREE miR-107 promotes growth and metastasis in GC via activation of PI3K-AKT signaling by targeting FAT4, which may be a target for GC treatment. 31297980 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE Furthermore, oxidative stress inhibited HER2-or PI3K-mediated tumor metastasis via the MST2-FoxO3a-ΔNp63α pathway. 31212215 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE The aims of this study were to develop original mouse models of patient-derived primary GC orthotopic xenografts (PDOX) allowing the development of distant metastases as preclinical models to study the anti-metastatic efficiency of drugs such as the phosphatidylinositol 3-kinase (PI3K) inhibitor Buparlisib (BKM120). 31010193 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression phenotype BEFREE Hsa_circ_0067934 is overexpressed and plays an oncogenic role in GBM by promoting cancer cell proliferation and metastasis via upregulation of PI3K-AKT pathway, which suggests that hsa_circ_0067934 is likely to serve as an efficient therapeutic approach in respect of GBM treatment. 31081099 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE MiR-181d inhibits cell proliferation and metastasis through PI3K/AKT pathway in gastric cancer. 31696473 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression phenotype BEFREE The elevated expression of TGF-β1 increases the PI3K/AkT/mTOR activity in human breast cancer tissue and potentially motivates tumor metastasis and resistance to chemotherapy. 31313132 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE These results indicate that KLF5 plays a significant role in HCC progression and metastasis and induces EMT via activating PI3K/AKT/Snail signaling, and the inhibition of KLF5 may be a potential treatment modality for patients with HCC. 30473218 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression phenotype BEFREE Further investigations found that TFAP4 promotes invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) and regulating MMP-9 expression via activating the PI3K/AKT signaling pathway in HCC. 31281549 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE The molecular mechanism of COE inhibited the metastasis may be related to the PI3K/Akt/mTOR signal pathway. 31364518 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE CNDP2 Acts as an Activator for Human Ovarian Cancer Growth and Metastasis via the PI3K/AKT Pathway. 31537175 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE Inotilone from Inonotus linteus suppresses lung cancer metastasis in vitro and in vivo through ROS-mediated PI3K/AKT/MAPK signaling pathways. 30787353 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways. 30894280 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression phenotype BEFREE TROP2 increases growth and metastasis of human oral squamous cell carcinoma through activation of the PI3K/Akt signaling pathway. 31638186 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker phenotype BEFREE TREM2 suppressed carcinogenesis and metastasis in HCC by targeting the PI3K/Akt/β-catenin pathway. 30683932 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 GeneticVariation phenotype BEFREE RE‑dMSP revealed a high concordance of 95.0% (153/161) with OSNA, and 100% (59/59) with PIK3CA mutation for detecting SN metastasis. 31638213 2019