Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 GeneticVariation group BEFREE Although other undiscovered mechanisms may be involved in the YY1-mediated tumor suppression role, the present study suggests that SOX2OT may act as a tumor promotor in PDAC and may represent a valuable diagnostic and therapeutic target. 28867247 2017
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 Biomarker group BEFREE The transcriptional regulator Yin Yang-1 (YY1) is a tumor suppressor known to be overexpressed in pancreatic cancer. 27074573 2016
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 Biomarker group BEFREE This regulatory effect of YY1 on glucose entry into the cells is critical for YY1-induced tumor cell proliferation and tumorigenesis. 29869834 2018
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 AlteredExpression group BEFREE Patients with higher expression of YY1 had larger tumor size, poor differentiation, higher TNM stage, and lymph node metastasis. 28972861 2017
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 Biomarker group BEFREE Further, these findings identify new targets such as TNF-alpha, NF-kappaB and YY1, whose inhibition can reverse tumor cell resistance to FasL-mediated apoptosis. 16784892 2006
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 Biomarker group CTD_human Molecular characterization of a cancer-related single nucleotide polymorphism in the pro-inflammatory interleukin-1B gene. 22467534 2012
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 Biomarker group BEFREE Different pattern of T cell receptor delta gene rearrangement in tumour-infiltrating lymphocytes and peripheral blood in patients with solid tumours. 7954530 1994
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 Biomarker group BEFREE In conclusion, MiR-7 is a novel miRNA with tumor suppressive function in colon cancer by targeting oncogenic YY1. 23208495 2013
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 Biomarker group BEFREE On the other hand, tumor suppressor roles of YY1 appear to involve YY1 stimulation of tumor suppressor BRCA1, increased Bax transcription and apoptosis involving cytochrome c release and caspase-3/-7 cleavage, induction of heme oxygenase-1, inhibition of pRb phosphorylation and p21 binding to cyclin D1 and cdk4, reduced expression of long noncoding RNA of SOX2 overlapping transcript, and MUC4/ErbB2/p38/MEF2C-dependent downregulation of MMP-10. 29322514 2018
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 AlteredExpression group BEFREE We further showed that overexpression of YY1 in cancer cells inhibited cell proliferation, foci formation and tumor growth in nude mice. 21666725 2012
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 GeneticVariation group BEFREE Clonal TCR gamma and delta gene rearrangements in lymphocytes from tumor compartment and peripheral blood were studied using TCR Vgamma and Vdelta gene primers in PCR followed by heteroduplex analysis. 15695120 2005
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 GeneticVariation group BEFREE TCR delta gene rearrangements or deletions were observed in all 50 T-cell neoplasms: 5 of 8 CD3- T-cell neoplasms showed rearrangements, whereas biallelic deletion of TCR delta gene was the most common pattern in CD3+ T-cell neoplasm (39 of 42 patients). 2554994 1989
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 Biomarker group BEFREE The multifunctional Yin-Yang 1 (YY1) is involved in the regulation of tumor malignancy of HCC. 31799179 2019
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 AlteredExpression group BEFREE Analysis of patients TMA tissues with prostatic cancer revealed higher expression of both YY1 and BclXL as a function of tumor grades and their levels were directly correlated. 23246440 2013
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 Biomarker group BEFREE This analysis demonstrates (1) a major subclass of human precursor T-cell neoplasms belonging to the gamma/delta T-cell receptor-rearranging subtype; (2) a narrow repertoire of human V delta gene usage; and (3) the utility of delta gene rearrangements as a diagnostic clonal marker in precursor T lymphoblastic neoplasms. 2478232 1989
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 AlteredExpression group BEFREE Expression of YY1 in CSCC tissues was not significantly correlated with tumor differentiation, but was significantly correlated with an advanced clinical stage of CSCC. 29470526 2018
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 AlteredExpression group BEFREE This demonstrated that TCR C delta gene expression was significantly higher in RCC compared to normal kidney (P < 0.019), suggesting a selective infiltration of gamma delta T cells into the tumour. 9111581 1997
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 Biomarker group BEFREE We show here that YY1 can suppress the growth of different tumor cell types in vitro, including human breast carcinoma cells and glioblastoma cells. 22322893 2012
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 AlteredExpression group BEFREE These results, together with the prior demonstration of augmentation of microtubule-related genes by E2F3, suggest that enhanced taxane sensitivity in tumors with high YY1/E2F activity may be mediated by modulation of putative target genes with microtubule function. 19208743 2009
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 Biomarker group BEFREE In contrast, one case of nasal lymphoma with CD2+CD3(Leu4)+CD8+CD19-CD56+ phenotype expressed full-length Talpha, Tbeta, and Tgamma transcripts rearranged TCR beta, gamma, and deleted TCR delta genes, indicating T-lineage, These results support the view that nasal lymphomas can separated into NK-cell and T-cell neoplasms, based on differences genotypic characteristics. 8698315 1996
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 Biomarker group BEFREE Here, we show that YY1 alters tumor cell metabolism by activating glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway. 29921695 2018
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 GeneticVariation group BEFREE Global analysis of gene expression demonstrated distinct clustering of tumors with and without YY1(T372R) mutations. 25787250 2015
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 Biomarker group BEFREE Finally, we discuss the possibility of therapeutically targeting the YY1 in cancers where it functions as a tumor promoter. 31824839 2019
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 AlteredExpression group BEFREE Overexpression of the TEF-1 delta protein by transfection was oncogenic in NIH3T3 cells as evidenced by the appearance of transformed foci exhibiting anchorage-independent growth and the potential to grow as tumors in nude mice. 11711542 2002
Entrez Id: 7528
Gene Symbol: YY1
YY1
0.400 PosttranslationalModification group BEFREE Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-κB in hepatocellular carcinoma. 26800240 2016