Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE Importantly, when fused to the tat protein-transduction sequence and subsequently introduced into cells, the C2 peptides potently promoted the RhoGAP function in DLC1, leading to decreased RhoA activation and reduced tumor cell growth in soft agar and migration in response to growth factor stimulation. 31806702 2020
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE A tumor suppressor DLC1: The functions and signal pathways. 31773748 2020
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE DLC1 was also identified as an estrogen-induced tumor suppressor in the normal mammary gland with decreased expression in breast cancer. 31110002 2019
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE Tripathi investigates how the tumor suppressor DLC1 is regulated by oncogenic kinases. 31515239 2019
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE Together, these findings indicate cooperation between the SRC, ERK1/2, and AKT kinases to reduce DLC1 Rho-GAP and tumor suppressor activities in cancer cells, which can be reactivated by the kinase inhibitors. 31308216 2019
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE Deleted in Liver Cancer 1 (DLC1) is a tumor suppressor gene deleted in many cancers, including angiosarcoma, an aggressive malignancy of endothelial cell derivation. 31409902 2019
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE So far, the role of the first identified member from the DLC family, DLC1, was established as a tumor suppressor in hepatocellular carcinoma. 30827083 2019
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE The tumor suppressor DLC1 inhibits cancer progression and oncogenic autophagy in hepatocellular carcinoma. 29785050 2018
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 AlteredExpression group BEFREE The findings indicate: 1) C3R (25 μM) has the potential to reduce RKO cell motility in vitro; 2) ingestion of lyophilized AP reduces the total number of aberrant crypt foci (ACF), ACF multiplicity, tumor cell proliferation and incidence of tumors with high grade dysplasia; 3) AP increases the gene expression of negative regulators of cell proliferation such as Dlc1 and Akt3, as well as inflammation (Ppara). 30194994 2018
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE Tumor suppressor gene DLC1 is shown to induce apoptosis, suppress migration and invasion in various cancer cells. 29964052 2018
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE Quantitative phosphoproteomic analysis identifies novel functional pathways of tumor suppressor DLC1 in estrogen receptor positive breast cancer. 30278072 2018
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE The Drosophila Crossveinless-c (Cv-c) RhoGAP is homologous to the human tumour suppressor proteins Deleted in Liver Cancer 1-3 (DLC1-3) sharing an identical arrangement of SAM, GAP and START protein domains. 29545526 2018
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE Deleted in Liver Cancer 1 (DLC1) is a tumor suppressor gene frequently deleted in cancer. 29202196 2018
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE Subsequent studies have demonstrated that DLC-1 is generally expressed in normal human tissues as well as in rats, while it always exists inactivated or even lost in many human cancers, which characterizes DLC-1 as a potential tumor suppressor. 27604574 2017
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 AlteredExpression group BEFREE That binding, which interferes with the interaction of RhoA-GTP with the RhoGAP domain, reduces the hydrolysis of RhoA-GTP, the binding of other DLC1 ligands, and the colocalization of DLC1 with focal adhesions and attenuates tumor suppressor activity. 29114068 2017
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE A tumor suppressor Deleted in Liver Cancer 1 (DLC1) has been reported to be down-regulated or even silenced in several kinds of cancer including breast cancer. 27830358 2017
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE DLC1 is a RhoGAP-containing tumor suppressor that inhibits angiogenesis by repressing VEGF production in epithelial cells. 28408355 2017
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 AlteredExpression group BEFREE This isoform is functional GAP protein and tumor suppressor and targeting of its expression results in the increase of DLC1 related cell processes: RHO activation and cell migration. 27614886 2016
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE DLC-1 has been identified as a candidate tumor suppressor. 27366946 2016
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE Deleted in liver cancer 1 (DLC1) on chromosome 8p22, is an important tumor suppressor gene originally identified to be deleted in hepatocellular carcinoma. 26986853 2016
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 AlteredExpression group BEFREE DLC-1 expression was not found to be associated with tumor differentiation status. 26514520 2015
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 AlteredExpression group BEFREE Lower expression levels of DLC1 indicated a more advanced tumor‑node‑metastasis stage, increased lymph node metastasis, deeper tumor invasion, increased tumor size and a higher rate of distant metastasis. 26239822 2015
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE DLC-1 inhibits cell growth and invasion in human colon cancer, functioning as a tumor-suppressor gene, possibly through the regulation of the Wnt/β-catenin signaling pathway. 24604602 2014
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 Biomarker group BEFREE These data suggest that DLC1 might act as a CHD-associated gene in addition to its role as a tumor suppressor in cancer. 24587289 2014
Entrez Id: 10395
Gene Symbol: DLC1
DLC1
0.400 AlteredExpression group BEFREE Restoration of DLC1 expression in GBC-SD and NOZ cells significantly reduced cell proliferation, migration in vitro, and the ability of these cells to form tumors in vivo. 24329682 2014