Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE Furthermore, the intracellular delivery of RNase A-QPN using a novel type of lipid-based nanoparticles, and subsequent protein activation by cellular NQO1, selectively inhibit cancer cell growth in vitro and effectively suppress tumor growth in vivo. 31589435 2019
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 AlteredExpression group BEFREE We found that NQO1 was frequently up-regulated in human liver cancer, and its high expression level was correlated with the tumor stage and low survival rate of HCC patients. 30867140 2019
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE Here, we demonstrate that NQO1-targeting prodrug β-lapachone triggers tumor-selective innate sensing leading to T cell-dependent tumor control. 31324798 2019
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE Here, we used NQO1-knockout (KO) mice to investigate the role of NQO1 in both the aging process and tumor susceptibility, specifically in the context of CR. 29733330 2019
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE Release of Lapa selectively increases tumor site-specific generation of H<sub>2</sub>O<sub>2</sub> via NAD(P)H: quinone oxidoreductase 1 (NQO1) catalysis. 31397998 2019
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE When the NQO1-proficient A549 tumors and NQO1-deficient MDA-MB-231 tumors were developed in the same animal, only the A549 malignancies activated the NIR-ASM probe with a strong signal. 31189950 2019
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 AlteredExpression group BEFREE Low NQO1 mRNA and protein levels were observed in the TP53 mutated subgroup compared to others tumors (p < .05) and in silico analyses of The Cancer Genome Atlas data further indicated that NQO1 mRNA levels were lower in serous compared to endometrioid copy-number high EC. 30908539 2019
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE Furthermore, the effect of NQO1 and SIRT6 on tumor growth was determined in cell model and orthotopic tumor implantation model. 31842909 2019
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE Notably, NQO1 inhibitor significantly enhanced the antitumor effects of THC in ESCC PDX tumors. 30737573 2019
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE Previous studies have shown that depleting tumor-NQO1 potentiates anoikis and inhibits growth of NSCLC. 29291405 2018
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE Therefore, our findings support that NQO1 displays a paradoxical role in mediating GBM growth in response to tumor suppressor PTEN. 30595797 2018
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 AlteredExpression group BEFREE Developing an effective method for detecting NQO1 activity with high sensitivity and selectivity in tumors holds a great potential for cancer diagnosis, treatment, and management. 30487423 2018
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 AlteredExpression group BEFREE Tumour tissue was analysed for NQO1 expression. 30318513 2018
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE NAD(P)H quinone oxidoreductase 1 (NQO1)-dependent antitumor drugs such as β-lapachone (β-lap) are attractive candidates for cancer chemotherapy because several tumors exhibit higher expression of NQO1 than adjacent tissues. 29434949 2018
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE Correction to: JNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress. 29880865 2018
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE Correction to: JNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress. 29880796 2018
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 AlteredExpression group BEFREE A novel anticancer agent RH1 is designed as pro-drug to be activated by NQO1, an enzyme overexpressed in many types of tumors. 28879492 2017
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 AlteredExpression group BEFREE NQO1 overexpression correlated to tumor size, venous infiltration and late pTNM stage of HCC. 28964792 2017
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 AlteredExpression group BEFREE NQO1: catalase levels (high in tumor, low in normal tissue) are an attractive therapeutic window to treat pancreatic cancer. 28346693 2017
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE Following activation by NQO1, IB-DNQ participates in a catalytic futile reduction/reoxidation cycle with consequent toxic reactive oxygen species generation within the tumor microenvironment. 27975234 2017
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 PosttranslationalModification group BEFREE Furthermore, NQO1 protects tumour suppressors like p53, p33<sup>ING</sup><sup>1b</sup> and p73 from proteasomal degradation. 28236663 2017
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE Releasing β-lapachone first from the CARNs selectively increases the ROS level in cancer cells via NAD(P)H:quinone oxidoreductase-1 (NQO1) catalysis, which induces the cascade amplification release of DOX and overcomes multidrug resistance (MDR) in cancer cells, producing a remarkably improved therapeutic efficacy against MDR tumors with minimal side effects. 28833669 2017
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 GeneticVariation group BEFREE This genomic gain was associated with amplification of the NQO1 gene in one tumor biopsy as well as in breast cancer cell lines. 26687450 2016
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE This translational study offers a potential biomarker-driven strategy using NQO1 expression to select tumors susceptible to β-lap-induced radiosensitization. 27196777 2016
Entrez Id: 1728
Gene Symbol: NQO1
NQO1
0.400 Biomarker group BEFREE NQO1 and HO-1 positive tumors showed nearly complete expression of Nrf2 in the nucleus and/or showed partial expression in the nucleus/cytoplasm (nNrf2); however, tumors negative for NQO1 and HO-1 showed almost complete expression of Nrf2 in the cytoplasm and/or partial expression in the nucleus/cytoplasm (cNrf2). 27033953 2016