Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 Biomarker group BEFREE FASN plays a critical role in supporting tumor cell growth, thus representing a potential target for anti-cancer therapies. 31775585 2020
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 AlteredExpression group BEFREE However, FAS is overexpressed in cancer cells and correlates with tumor malignancy, which makes FAS an attractive selective therapeutic target in tumorigenesis. 31811668 2020
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 AlteredExpression group BEFREE The results indicated that RA-XII strongly inhibited tumor growth and lipogenesis (triglycerides and lipid droplets) in HepG2 cells, and the expression of key factors involved in lipogenesis (SREBP, SCD, FASN) was also obviously downregulated. 31083642 2019
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 Biomarker group BEFREE In vivo, genetic deletion or pharmacologic inhibition of FASN before oncogenic activation prevents tumor development and invasive growth. 31676791 2019
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 Biomarker group BEFREE Furthermore, elevated serum levels of HIF-1α and FASN and expression of HIF-1α, SREBP-1c and FASN genes were associated with unfavorable clinicopathological features such as diffuse type tumor and poor survival. 30914315 2019
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 AlteredExpression group BEFREE High FASN expression was observed in 56.7% (34/60) of NMIBC cases, and FASN expression was significantly associated with the tumor size, grade, and tumor stage (p = 0.003, p < 0.001, p < 0.0001 respectively). 30684846 2019
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 AlteredExpression group BEFREE <b>Results:</b> FASN level was upregulated in CRC tissues and high expression of FASN was significantly associated with lymph node metastasis, TNM (Tumor, Node, Metastases) stage and poor prognosis in patients with CRC. 31118685 2019
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 Biomarker group BEFREE The xenograft mouse model was used to evaluate tumor weights after suppression of FASN. 31122252 2019
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 AlteredExpression group BEFREE We further demonstrated that MEX3C regulated lipid metabolism and promoted tumor development and progression through activation of JNK signaling and upregulating the JNK downstream protein levels of sterol regulatory element-binding proteins-1, fatty acid synthase and acetyl-CoA carboxylase-1. 31118679 2019
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 Biomarker group BEFREE The FASN inhibitor orlistat is a 'dirty' drug with target-off actions upon at least seven targets with a proven role in tumor biology. 29723075 2018
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 Biomarker group BEFREE All metastatic melanomas tested had at least 25% tumor cell staining for both FASN and ACC. 28654463 2018
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 AlteredExpression group BEFREE The present study investigated FASN protein expression in 18 randomly selected pairs of GC tumors and matched normal tissues by western blot analysis. 29928446 2018
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 Biomarker group BEFREE We evaluated the effect of TVB-3664 on tumor growth in nine CRC patient-derived xenografts (PDXs) and investigated molecular and metabolic changes associated with CRC responsiveness to FASN inhibition. 29872506 2018
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 AlteredExpression group BEFREE Accordingly, inhibiting FASN by FASN inhibitor can partly restore the immunostimulatory activity of TIDCs and extended tumor control by evoking protective anti-tumor immune responses. 30619288 2018
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 AlteredExpression group BEFREE This differential association appeared to be consistent in strata of tumor microsatellite instability or FASN expression status, although the statistical power was limited. 28510098 2017
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 Biomarker group BEFREE Collectively, these results suggest that the altered lipid metabolism found in <i>NF2</i>-mutant cells renders them sensitive to elevated levels of malonyl-CoA, as occurs following blockade of FASN, suggesting new targeted strategies in the treatment of <i>NF2</i>-deficient tumors.<i></i>. 28729415 2017
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 AlteredExpression group BEFREE PEITC administration to TRAMP mice also resulted in a significant decrease in tumor expression of FASN protein. 28292742 2017
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 Biomarker group BEFREE Inhibiting FASN leads to tumor cell death while sparing normal cells, which do not have the dependence of this enzyme for normal functions, and restores membrane architecture to more normal properties thereby resensitizing tumors to killing by chemotherapies. 28202364 2017
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 Biomarker group BEFREE However, we did not observe statistically significant interactions of insulin scores with PIK3CA, FASN, or any other tumor marker (p interaction > 0.12). 28268248 2017
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 Biomarker group BEFREE In lung, ovarian, prostate, and pancreatic tumor xenograft studies, FASN inhibition and paclitaxel or docetaxel combine to inhibit xenograft tumor growth with significantly enhanced anti-tumor activity. 28159572 2017
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 Biomarker group BEFREE Coexpression of fatty acid binding protein (FABP1) and fatty acid synthase (FASN) in gastric cancer tissues (61.4% sensitivity and 77.1% specificity) was strongly associated with lymph node metastasis and Tumor, Node, Metastasis stage I/II. 27884752 2017
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 Biomarker group BEFREE High levels of fatty acid synthase (FAS) expression have been found in many tumors, including prostate, breast, and ovarian cancers, and inhibition of FAS has been reported to obstruct tumor growth in vitro and in vivo. 26985864 2016
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 Biomarker group BEFREE Inhibition of FASN using shRNAs or C75 decreased tumor growth, prolonged the overall survival of xenograft mice and decreased MVD in brain tumor sections. 27601165 2016
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 AlteredExpression group BEFREE Fatty acid synthase (FASN), a lipogenic multi-enzyme complex, is reported to be overexpressed in various types of of tumor tissues and serves an important role in tumor development and progression. 26936091 2016
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.400 Biomarker group BEFREE STRING analysis confirmed protein-protein-interactions of regulated genes and Western immunoblotting of fatty acid synthase, serine hydroxyl-methyltransferase 1, arginine 1 and hexokinase 2 showed tumor specific induction. 27602772 2016