Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 AlteredExpression group BEFREE In addition, in vivo experiments showed that miR-1827 inhibited tumor growth by reducing the levels of MYC and FAM83F. 31595558 2020
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 AlteredExpression group BEFREE We, for the first time, showed that AF increased CD8<sup>+Ve</sup> T-cell tumor infiltration in vivo and upregulated immune checkpoint PD-L1 expression in an ERK1/2-MYC-dependent manner. 31090219 2020
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 GeneticVariation group BEFREE Alterations in cell cycle regulation-associated genes, such as genetic mutations and MYC copy number gain, may promote primary progression from low-grade GISTs to high-grade tumors by regulating tumor cell proliferation. 31570771 2020
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker group BEFREE The MAP3K13-TRIM25-FBXW7α axis affects c-Myc protein stability and tumor development. 31186535 2020
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker group BEFREE A new MYC inhibitor reduced tumor growth in mouse prostate cancer models. 31704724 2020
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 AlteredExpression group BEFREE Protein arginine methyltransferase 5 represses tumor suppressor miRNAs that down-regulate CYCLIN D1 and c-MYC expression in aggressive B-cell lymphoma. 31822509 2020
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker group BEFREE Genome-wide sequencing analyses of metastatic variants identified semaphorin 4D (SEMA4D) as a regulator of tumor cell transmigration through the blood-brain-barrier and MYC as a crucial regulator for the adaptation of disseminated tumor cells to the activated brain microenvironment. 31601552 2020
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker group BEFREE miR-29a is repressed by MYC in pancreatic cancer and its restoration drives tumor suppressive effects via downregulation of LOXL2. 31662451 2020
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 AlteredExpression group BEFREE Macrophage function and tumor-cell MYC expression may contribute to the PD-1-independent adverse prognostic effect of PD-L1<sup>+</sup> expression. 30666052 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 AlteredExpression group BEFREE These findings establish MYC repression as a mechanism for ZFHX3's tumor suppressor activity and ZFHX3 as an indispensable factor for ERβ's tumor suppressor activity in prostate cancer cells. 30979864 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker group BEFREE We used human and mouse tumor-derived cell lines, tumor xenografts, and four conditional transgenic mouse models of MYC-induced tumors to show that MYC regulates lipogenesis genes, enzymes, and metabolites. 31447321 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker group BEFREE The changes in tumor cell metabolism after EPHB4 inhibition were associated with MYC downregulation, likely mediated by the SRC/p38 MAPK/4EBP1 signaling cascade, known to impair cap-dependent translation. 31641103 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker group BEFREE To date, functions of PLK1 and MYC on tumor are mostly studied in separate researches, and studies on their mutual crosstalk are lacking. 31571905 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker group BEFREE In both cases, the proliferating cells and the tumor displayed MYC and BCL2 rearrangements. 30277098 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker group BEFREE Intratumoural clonal diversity of MYC amplification was also observed, with a significant degree of variance in amplification ratios (Bartlett's test for equal variance p < 0.001), and an association between greater variance in MYC amplification and improved outcome with prior first-line chemotherapy. ddPCR was most accurate in quantifying MYC amplification in tumour-derived DNA from cases with a high proportion (>70%) of amplified cells within the tumour specimen but was not reliable in samples containing a low proportion of amplified cells or in ctDNA. 31606655 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 AlteredExpression group BEFREE C-MYC expression promoted high proliferation rates of MSC, attenuated but not abrogated their differentiation capacity, and did not immediately lead to tumor formation in the tested in vivo mouse model. 30836996 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker group BEFREE These findings implicate a crucial role for MYMLR in regulation of the archetypical oncogene MYC and warrant future studies regarding the involvement of low copy number lncRNAs in regulation of other crucial oncogenes and tumor suppressor genes. 31361039 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 AlteredExpression group BEFREE LMX1A inhibits C-Myc expression through ANGPTL4 to exert tumor suppressive role in gastric cancer. 31557193 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 AlteredExpression group BEFREE We also found that FBXW7 expression in CD133-positive cells was increased and c-MYC expression was decreased in gefitinib-resistant tumors of PC9 cells in mice and in 9 out of 14 tumor specimens from EGFR-mutant NSCLC patients with acquired resistance to gefitinib. 31202256 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker group BEFREE Multivariate Cox regression analysis revealed that TN stage (<i>P</i><0.001), American Joint Committee on Cancer (AJCC) stage (<i>P</i><0.0001), and tumor differentiation (<i>P</i>=0.0025) were independent factors for overall survival in patients with OSCC except for c-MYC expression (<i>P</i>>0.05). 31239771 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker group BEFREE We demonstrate that pharmacological reactivation of MYC-dependent apoptosis is a powerful antitumor strategy involving both tumor cell depletion and immunosurveillance. 30728358 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 AlteredExpression group BEFREE Cox univariate and multivariate analyses showed that HIF-1α and c-myc protein expression, histological grade, lymph node status, and tumor TNM stage were the independent risk factors for postoperative survival in TNBC patients. 31577739 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 AlteredExpression group BEFREE The tumor suppressor role of miR-29 is mediated by the activation of JAK/STAT1 signaling that further plays a role in MYC-B7-H3 downregulation in MB. 31382461 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 AlteredExpression group BEFREE We found that cellular senescence and tumor regression upon MYC inactivation in T-ALL was associated with genome-wide changes in 5mC and 5hmC patterns. 31266538 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker group BEFREE The concept that SNF5 is a coactivator for MYC, however, is at odds with its role as a tumor-suppressor, and with observations that loss of SNF5 leads to activation of MYC target genes. 31043611 2019